Estradiol

Estradiol is a female sex hormone (estrogen). This is a type of hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness, and itching), estrogen deficiency, and thinning of bones (osteoporosis). In some cases, Estradiol is also used to treat breast cancer and prostate cancer along with other anticancer medicines. The medicine is to be swallowed with water. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed a dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine. The most common side effects of this HRT are headaches, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. Some of the warning signs and symptoms that need immediate medical attention are breast lumps, unusual vaginal bleeding, dizziness and faintness, severe headaches, chest pain, shortness of breath, pains in your legs, etc. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body. Estradiol is an estrogen (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).

• Hormone replacement therapy

Estradiol is a naturally occurring oestrogen. Oestrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH and FSH through a negative feedback system.

Adult Dose: Oral Vulvar and Vaginal Atrophy in Menopause Adult: 1-2 mg PO once daily for 3 weeks, followed by 1 week off Prevention of osteoporosis: 0.5 mg PO once daily for 3 weeks, followed by 1 week off Metastatic breast cancer: 10 mg PO q8hr for 3 months Prostate cancer: 1-2 mg PO q8hr for ?3 months

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Estradiol may be taken with or without food, but it is better to take it at a fixed time.

Common: • Headache • Nausea • Breast pain • Abdominal cramp • Bloating • Vaginal spotting • Vomiting

[SAFE] Estradiol does not usually affect your ability to drive. You have been prescribed Estradiol as a part of hormone replacement therapy to relieve symptoms of menopause. It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures. Take it at the same time everyday to help you remember to take it. Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Estradiol. It may increase the risk of breast cancer. Have regular breast examinations. Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Hypersensitivity; undiagnosed vag bleeding; thrombophloebitis or thromboembolic disorders; breast carcinoma except in selected patients being treated for metastatic disease; oestrogen-dependent tumor; porphyria; pregnancy.

CYP1A2 and CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together.

[CAUTION] Caution is advised when consuming alcohol with Estradiol. Please consult your doctor.

[CONSULT YOUR DOCTOR] Estradiol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[UNSAFE] Estradiol is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Estradiol should be used with caution in patients with kidney disease. Dose adjustment of Estradiol may be needed. Please consult your doctor. [CAUTION] Estradiol should be used with caution in patients with liver disease. Dose adjustment of Estradiol may be needed. Please consult your doctor. Use of Estradiol is not recommended in patients who previously had liver disease and the liver function tests are still not normal.

I am a male to female transsexual and I need Bilateral Orchiectomy at a fair cost I am already on hormone replacement therapy for 2 years anti androgen/spirnolactone (Aldactone) and estrodiol valerate progynova, I need to have bilateral orchiectomy at the cheapest option Hi Kindly consult to your nearest doctor I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement. We are planning our baby.my doctor has prescribed me progynova tablets.but in this app it is written it used post menopause.please suggest Hi Progyva is an oestrogen containing medicine. It si usually prescribed in patients with menopause. Its role in infertility is very limited and not common. Male hormone testosterone is found less in the recent blood test around 270,shall I take hormone therapy like tablet cents regularly what will be the dose and limitations in use Hi Kindly consult to Allopathic doctor Blood test E2 is at level 104, after taking progynova 1mg tab for 10 days, before 5 days it was at 99. I am consulting my wife for IVF How should I go ahead doctor. E2 in itself does not indicate much.please send in all your reports I am having progynova 2mg twice a day. Duphaston 10 mg twice a day from Day 18 to 28 of my cycle. I started my periods yesterday. I am having sevior pain. I read that headache, heavy periods are a normal side effect of Duphaston. My IVF cycle will start soon. Is there an alternative to Duphaston with fewer side effects?? Yes vaginally used progesterone i have done iui treatment few days back to conceive pregnancy.my doctor suggested me to take duoluton l daily at night.my query is why is this tablet suggested.can i get pregnant after using this tablet. It is hormonal replacement which is good Is stem cell therapy advisable over regular regular knee replacement surgery for regeneration on cartilage in knees. This is very new and the long-term studied about the same are yet not available