৳ 19/unit
Pack: ৳ 190
৳ 19/unit
Pack: ৳ 190
At a glance
Estradiol is a female sex hormone (estrogen) used as hormone replacement therapy for menopause symptoms, estrogen deficiency, and osteoporosis.
Indications
- Hormone Replacement Therapy: Used for treatment of menopause symptoms such as hot flushes, night sweats and mood swings.
- Vaginal Atrophy: Used for treatment of vaginal dryness and itching during menopause.
- Osteoporosis Prevention: Used for prevention of bone loss in postmenopausal women.
- Metastatic Breast Cancer: Used for palliative treatment in selected patients.
- Prostate Cancer: Used for palliative treatment.
Pharmacology
Estradiol is a naturally occurring oestrogen. Oestrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH and FSH through a negative feedback system.
Dosage
Adult Dose (Oral):
- Vulvar and Vaginal Atrophy in Menopause: 1-2 mg PO once daily for 3 weeks, followed by 1 week off
- Prevention of osteoporosis: 0.5 mg PO once daily for 3 weeks, followed by 1 week off
- Metastatic breast cancer: 10 mg PO q8hr for 3 months
- Prostate cancer: 1-2 mg PO q8hr for >=3 months
Elderly and Hepatic impairment: Dose adjustment may be needed.
Side effects
Common Side Effects:
- Headache
- Nausea
- Breast pain
- Abdominal cramp
- Bloating
- Vaginal spotting
- Vomiting
- Hair loss
Use in pregnancy
Use in Pregnancy: Category B3. Estradiol may be unsafe to use during pregnancy. Animal studies have shown harmful effects on the developing baby.
Pregnancy Category: B3 — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Estradiol does not usually affect your ability to drive.
- Prescribed as part of HRT to relieve symptoms of menopause.
- Take at the same time every day.
- Inform your doctor if you experience any unusual vaginal bleeding, discharge or vaginal discomfort.
- May increase risk of breast cancer; have regular breast examinations.
- Stop taking and inform doctor immediately if unexplained swelling and pain in limbs, shortness of breath, chest pain, or changes in vision occur.
Overdose effects
Overdose: Overdose may cause nausea and vomiting and withdrawal bleeding may occur. No specific antidotes; symptomatic treatment.
Storage conditions
Storage: Store below 30 degree C in a cool and dry place, away from light. Keep out of reach of children.