Ezetimibe

Ezetimibe is a medicine used to treat high cholesterol. This medicine helps by lowering "bad" cholesterol (LDL) levels in blood. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Ezetimibe should be taken in the dose and duration as advised by the doctor. You can take it at any time of day but try to take it at the same time each day. Most people with high cholesterol do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your cholesterol levels rising up again and increase your risk of heart disease and stroke. It is important to have your cholesterol levels checked regularly. This medicine is only one part of a treatment program which should also include a healthy diet, regular exercise, smoking cessation, moderation of alcohol intake and weight reduction. You can eat normally while taking this medicine, but try to avoid foods that are high in fat. Common side effects of this medicine include joint pain and diarrhea. Before taking this medicine its better to let your doctor know about all the other medicines that are prescribed to you. This medicine should be taken with caution if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should not take this medicine without consulting the doctor. Ezetimibe is a cholesterol absorption inhibitors. It reduces the cholesterol absorption from the intestine and lowers the levels of total cholesterol and "bad" cholesterol (LDL) in the blood.

• High cholesterol

Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, thus decreasing its delivery to the liver. This results in decrease in cholesterol stores within the liver and an increase in cholesterol clearance from the blood.

Adult Dose: Oral Hyperlipidaemias; Homozygous familial sitosterolaemia Adult: 10 mg once daily. Hepatic impairment Mild (Child-Pugh class A): Dose adjustment not necessary Moderate to severe (Child-Pugh class B or C): Not recommended Child Dose: Child: >10 yr: 10 mg once daily. Renal Dose: Renal impairment Monotherapy: No dosage adjustment required Moderate to severe: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ezetimibe may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Ezetimibe, skip it and continue with your normal schedule. Do not double the dose.

Common: • Joint pain • Sinus inflammation • Diarrhea • Respiratory tract infection

[UNSAFE] Ezetimibe may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Ezetimibe treats high cholesterol by lowering bad cholesterol (LDL) and raising good cholesterol (HDL). This helps prevent heart attack and stroke. Take it in addition to regular exercise and low-fat diet. Notify your doctor if you experience muscle symptoms (pain or weakness), particularly if accompanied with fever. Do not stop taking the medication suddenly without talking to your doctor.

Hypersensitivity; moderate to severe liver disease or unexplained serum transaminase elevation. Children <10 yr, lactation.

Reduced absorption w/ colestyramine. Increased plasma concentrations w/ ciclosporin. Concomitant use w/ oral anticoagulants may result in increased INR.

[UNSAFE] It is unsafe to consume alcohol with Ezetimibe.

[CONSULT YOUR DOCTOR] Ezetimibe may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ezetimibe is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Ezetimibe is safe to use in patients with kidney disease. No dose adjustment of Ezetimibe is recommended. [CAUTION] Ezetimibe should be used with caution in patients with liver disease. Dose adjustment of Ezetimibe may be needed. Please consult your doctor. Use of Ezetimibe is not recommended in patients with moderate to severe liver disease.

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