Fluticasone Furoate inhalation

Introduction: Fluticasone Furoate inhalation powder is a steroid used for the prophylactic treatment of asthma. It works by blocking the production of certain chemical messengers that cause inflammation and allergies.

How it works: Fluticasone Furoate is a synthetic, fluorinated corticosteroid with potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically.

Important Information: This inhalation is not indicated for the relief of acute bronchospasm. Use at the same time every day and do not use more than once every 24 hours.

• Asthma prophylaxis: Once-daily maintenance treatment as prophylactic therapy in patients aged 5 years and older.
• Not indicated for the relief of acute bronchospasm.

Nasal Steroid Preparations

Synthetic corticosteroid

Fluticasone Furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. It utilises a fluorocarbothioate ester linkage that provides potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically.

Fluticasone Furoate binds to glucocorticoid receptors and inhibits the migration of inflammatory mediators and cells, resulting in reduced lung inflammation and asthma control.

Adults and Adolescents Aged 12 Years and Older:

• Starting dose: 100 mcg once daily.
• May increase to 200 mcg after 2 weeks if no response.
• Maximum: 200 mcg/day.

Pediatric Patients Aged 5 to 11 Years:

• 50 mcg once daily.

Hepatic Impairment:

• Mild: No dosage adjustment required.
• Moderate-to-severe: Caution advised.

* Use as directed by the registered physician

Inhalation capsule - administer as 1 inhalation once daily. Use at the same time every day. Do not use more than once every 24 hours.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.

Common Side Effects (≥5%):

• Nasopharyngitis
• Bronchitis
• Upper respiratory tract infection
• Headache

Pediatric (≥3%):

• Pharyngitis
• Bronchitis
• Viral infection

Precautions:

• Do not use in acute asthma attacks (fast-acting bronchodilator needed).
• Seek medical advice if asthma symptoms remain uncontrolled or worsen.
• Paradoxical bronchospasm may occur - use bronchodilator immediately and discontinue.
• Avoid in patients with severe allergy to milk protein.

Contraindications:

• Status asthmaticus or other acute episodes of asthma
• Hypersensitivity, including severe allergy to milk protein

Drug Interactions:

• Potent CYP3A4 inhibitors (e.g., ritonavir) may increase plasma concentration.

Food Interactions: No interaction found/established.

Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects. Your doctor will weigh the benefits and risks.

Use in Lactation: Probably safe during breastfeeding. Limited data suggests the drug does not represent any significant risk to the baby.

Pediatric Use: Dosage available for children aged 5 years and older. No data available for children under 5 years.

Geriatric Use: Dose selection should be cautious in elderly patients.

Renal Impairment: No dosage adjustment required for any severity.

Hepatic Impairment: Use with caution in severe hepatic impairment.

Overdose: Limited information available on overdose. Employ usual supportive measures.

Storage: Store at a temperature not exceeding 30°C. Do not refrigerate. Protect from light and moisture.

Fluticasone Furoate Inhalation Powder