Folic Acid + Vitamin B6 + Vitamin B12

Introduction: Folic Acid + Vitamin B6 + Vitamin B12 is a combination vitamin supplement used for neurological disorders, hyperhomocysteinemia, renal disease and vitamin B12 deficiency.

How it works: Folic acid is required for nucleoprotein synthesis and maintenance of normal erythropoiesis. Vitamin B6 plays a role in lipid metabolism, carbohydrate metabolism and tissue respiration. Vitamin B12 is required for maintenance of normal erythropoiesis, nucleoprotein and myelin synthesis.

• Hyperhomocysteinemia
• Cardiovascular disease
• Neurological disorders
• Renal disease
• Vitamin B12 deficiency
• End-stage renal failure
• Peripheral vascular disease
• Dialysis

Vitamin-B preparations

Water-soluble vitamins

Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; converted to tetrahydrofolic acid by dihydrofolate reductase; prevents neural tube defects. Vitamin B6: Plays a role in the synthesis and maintenance of coenzyme A. Necessary for lipid metabolism, carbohydrate metabolism, tissue respiration, glycogenolysis. Vitamin B12: Required for the maintenance of normal erythropoiesis, nucleoprotein and myelin synthesis, cell reproduction and normal growth.

Folic acid aids in DNA synthesis. Vitamin B6 plays a role in amino acid metabolism. Vitamin B12 aids in myelin formation and red blood cell production.

Adult Dose:

• Daily Dietary Supplement: 1-2 tablets daily.

* Use as directed by the registered physician

Oral tablet. Can be taken with or without food. Swallow whole.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.

Common Side Effects:

• Folic acid: Allergic sensitization (rare).
• Vitamin B6: Paresthesia, somnolence, nausea and headache.
• Vitamin B12: Mild transient diarrhea, polycythemia vera, itching, rash.

Precautions:

• Folic acid when administered as a single agent in doses above 0.1 mg daily may obscure pernicious anemia.
• Unmetabolized Folic Acid has the potential to reduce natural killer cells' cytotoxicity, which may result in an impaired immune response.

Contraindications:

• Known hypersensitivity to any of the components in the product.

Drug Interactions:

• Folic acid: Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, methotrexate may decrease serum folate concentrations. Decreases serum phenytoin concentrations.
• Vitamin B12: Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine.

Food Interactions: No interaction found/established.

Use in Pregnancy: Safe in pregnancy and recommended for neural tube defect prevention.

Use in Lactation: Drug enters breast milk; safe for nursing.

Pediatric Use: Use as per doctor's advice for children.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal & Hepatic Impairment: No known restrictions.

Overdose: Overdose may cause gastrointestinal disturbances. Symptomatic treatment should be given.

Storage: Store below 30°C, in a dry place, away from light. Keep out of reach of children.

Folic Acid + Vitamin B6 + Vitamin B12 Tablet