Generic
Garlic Oil
4 brands available in the market
At a glance
Garlic Oil is a herbal supplement used for hyperlipidemia, atherosclerosis and mild hypertension.
Description
Introduction: Garlic Oil is prepared from the whole fresh bulb, the dried bulb and the oil of Garlic. Garlic contains alliin and its transformation products and sulfur containing essential oil. Garlic oil is not present in fresh or dried garlic bulbs, instead the oil is produced by converting water-soluble thiosulfinates to oil-soluble sulfides via steam distillation.
How it works: Garlic reduces total cholesterol (TC), serum triglycerides (TG) and elevates high density lipoproteins (HDL). It prevents platelet aggregation and thrombus formation, stimulates fibrinolysis, prolongs clotting time, reduces low density lipoprotein (LDL) oxidation. It also reduces systolic and diastolic blood pressure and attenuates age and blood pressure related increases in aortic stiffness and reduces blood glucose levels.
Important Information: 1 to 2 capsules daily for 8 to 18 weeks or as advised by the physician. Concurrent use with antiplatelet agents and anticoagulants might increase the potential for prolonged bleeding.
Indications
- Hyperlipidemia
- Atherosclerosis
- Mild Hypertension
Therapeutic class
Herbal and Nutraceuticals
Pharmacological class
Herbal Supplement
Pharmacology
Garlic reduces total cholesterol (TC), serum triglycerides (TG) and elevates high density lipoproteins (HDL). It prevents platelet aggregation and thrombus formation, stimulates fibrinolysis, prolongs clotting time, reduces low density lipoprotein (LDL) oxidation. It also reduces systolic and diastolic blood pressure and attenuates age and blood pressure related increases in aortic stiffness and reduces blood glucose levels. Steroid saponins interfere with the absorption of total and LDL cholesterol from the intestinal lumen, thereby reducing plasma cholesterol level without adversely affecting HDL levels. Increases catabolism of fatty acid-containing lipids, especially triglycerides.
Mechanism of action
Garlic inhibits HMG-CoA reductase to reduce cholesterol synthesis, prevents platelet aggregation and reduces blood pressure.
Dosage
Adult Dose:
- 1 to 2 capsules daily for 8 to 18 weeks or as advised by the physician.
Administration
Oral capsule. Can be taken with or without food. Take in the dose and duration as advised by your doctor.
Missed dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.
Side effects
Common Side Effects:
- Gastro-intestinal symptoms
- Changes to the flora of the intestine
- Allergic reactions - rare
Precautions & warnings
Precautions:
- Caution in patients with known allergy to garlic.
- Caution in patients taking warfarin (blood clotting times may double).
- Concurrent use with antiplatelet agents and anticoagulants might increase the potential for prolonged bleeding.
Contraindications
Contraindications:
- No known contraindications. However, caution in patients with garlic allergy and those taking warfarin.
Drug interactions
Drug Interactions:
- Concurrent use with antiplatelet agents and anticoagulants might increase the potential for prolonged bleeding.
- Blood clotting times have been reported to double in patients taking warfarin and garlic supplements.
Food interactions
Food Interactions: No interaction found/established.
Use in pregnancy
Use in Pregnancy: No known contraindications. However, consult your doctor before use.
Pregnancy Category: NA — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Major sulfur containing volatiles from garlic are transmitted to breast milk leading to improved drinking habits of infants.
Pediatric use
Pediatric Use: Use as per doctor's advice for children.
Geriatric use
Geriatric Use: Use as per doctor's advice for elderly patients.
Renal / hepatic impairment
Renal & Hepatic Impairment: No known restrictions. However, consult your doctor.
Overdose effects
Overdose: Overdose may cause gastrointestinal symptoms. Symptomatic treatment should be given.
Storage conditions
Storage: Store at a cool, dry place and away from direct sunlight. Keep out of reach of children.
Chemical structure
Garlic Oil Capsule