Generic
Human normal Immunoglobulin
4 brands available in the market
At a glance
Human normal Immunoglobulin is used to strengthen the body's natural immune system to lower the risk of infection in persons with weakened immune system.
Description
Human normal Immunoglobulin is used to strengthen the body's natural immune system to lower the risk of infection in persons with weakened immune system. It is made from healthy human blood that has a high level of certain defensive substances (antibodies), which help fight infections. It is effective in treatment of primary immunodeficiency states where severe impairment of antibody forming capacity is there. Both children and adults can have this therapy. It is administered intravenously.
Indications
- Immunoglobulins deficiency
- Primary immunodeficiency
Therapeutic class
Vaccines, Anti-sera & Immunoglobulin
Pharmacological class
Immunostimulant
Pharmacology
Human normal immunoglobulin is derived from donations of pooled human plasma. It contains antibodies, mainly immunoglobulin G (IgG), to various bacteria and viruses present in the general population such as hepatitis A, measles, mumps, rubella and varicella. It has a distribution of IgG subclasses that is very close to that of the normal human plasma.
Mechanism of action
Human normal immunoglobulin provides passive immunization by supplying antibodies to the body, which helps fight against infections.
Dosage
Adult Dose (IV):
- Severe bacterial/viral infections and A-/Hypogammaglobulinemia: 2500-5000 mg single dose IV infusion
- ITP: 200-400 mg/kg daily for 5 days
- Guillain-Barre Syndrome: 400 mg/kg daily for 5 days
- Kawasaki Syndrome: 400 mg/kg daily for 5 days or 2000 mg daily IV infusion
Child Dose:
- Neonates and infants: 5 ml (250 mg)/kg daily for 3 days
- Severe infections and A-/Hypogammaglobulinemia: 50-150 mg/kg single dose
- ITP: 200-400 mg/kg daily for 5 days
- Guillain-Barre Syndrome: 400 mg/kg daily for 5 days
- Kawasaki Syndrome: 400 mg/kg daily for 5 days
Administration
Your doctor or nurse will give you this medicine; do not self-administer. Administered as intravenous infusion. Warm to room temperature before use.
Missed dose
If you miss a dose of Human normal Immunoglobulin, please consult your doctor.
Side effects
Common Side Effects:
- Back pain
- Chills
- Flushing (warmth in face, ears, neck and trunk)
- Dizziness
- Headache
- Nausea
- Decreased blood pressure
- Muscle pain
- Slow heart rate
- Wheezing
Precautions & warnings
Precautions:
- Human normal Immunoglobulin may affect your ability to drive
- Side effects like dizziness or nausea may occur during treatment
- Doctor will monitor you for some time after administration
- Inform doctor if you have received any live vaccine (oral polio, MMR) in the last three months
- Caution in patients with IgA antibodies
Contraindications
Contraindications:
- Hypersensitivity to human Ig
- Circulating Abs to IgA
Drug interactions
Drug Interactions:
- May interfere with immune response to live measles, mumps, rubella and varicella vaccines; vaccines should be given at least 3 weeks before or 3 months after immunoglobulin administration
Food interactions
It is not known whether it is safe to consume alcohol with Human normal Immunoglobulin; consult your doctor.
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and potential risks.
Use in lactation
Use in Lactation: Use with caution; breastfeeding should be held until treatment is completed and drug is eliminated from body.
Pediatric use
Dose for children provided above.
Geriatric use
No specific dosage adjustment needed for elderly.
Renal / hepatic impairment
Renal Impairment: Use with caution; dose adjustment may be needed.
Hepatic Impairment: Probably safe; dose adjustment may not be needed.
Overdose effects
No specific overdose reactions known; provide symptomatic treatment.
Storage conditions
Store and transport at +2°C to +8°C; protect from light; do not freeze; keep out of reach of children.
Chemical structure
Human normal Immunoglobulin