Generic
Hydroquinone + Tretinoin + Mometasone Furoate
8 brands available in the market
At a glance
Hydroquinone + Tretinoin + Mometasone Furoate cream is used for the short-term treatment of moderate to severe melasma of the face.
Description
Hydroquinone + Tretinoin + Mometasone Furoate cream is used for the short-term treatment of moderate to severe melasma of the face. This cream contains three active ingredients: Fluocinolone Acetonide (anti-inflammatory corticosteroid), Hydroquinone (depigmenting agent) and Tretinoin (keratolytic agent). After starting treatment, avoid sun exposure and use sunscreen of at least SPF 30 or more.
Indications
- Moderate to severe melasma of the face (short-term treatment)
Therapeutic class
Hydroquinone Preparations
Pharmacological class
Corticosteroid + Depigmenting Agent + Keratolytic Agent
Pharmacology
This cream contains three active ingredients used to treat melasma. Fluocinolone Acetonide is a topical corticosteroid with anti-inflammatory action. Hydroquinone is a depigmenting agent that may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. Tretinoin is a keratolytic agent that increases skin cell turnover.
Mechanism of action
Hydroquinone reduces melanin production; Tretinoin increases skin cell turnover; Mometasone reduces inflammation and irritation.
Dosage
Adult Dose (Topical):
- Apply once daily at night (at least 30 minutes before bedtime)
- Gently wash face and neck with mild cleanser; rinse and pat dry
- Apply a thin film to hyperpigmented areas of melasma including about ½ inch of normal-appearing skin surrounding each lesion
- Rub lightly and uniformly into the skin
- During the day, use sunscreen and wear protective clothing; avoid sunlight exposure
Pediatric Use: Safety and efficacy not established
Administration
For external use only; apply once daily at night 30 minutes before bedtime; clean face with mild cleanser and pat dry; apply thin film; use sunscreen during the day.
Missed dose
If you miss a dose, apply it as soon as possible; if it is almost time for your next dose, skip the missed dose.
Side effects
Side Effects:
- Mild to moderate redness
- Skin peeling
- Burning sensation
- Dryness
- Itching
- Hypersensitivity (rare)
Precautions & warnings
Precautions:
- Hydroquinone and Tretinoin may cause mild to moderate irritation
- Local irritation (skin reddening, peeling, mild burning, dryness, pruritus) is expected
- Transient skin reddening or mild burning sensation does not preclude treatment
- If reaction suggests hypersensitivity or chemical irritation, discontinue medication
- Systemic absorption of topical corticosteroids can produce HPA axis suppression
- Avoid use of medicated or abrasive soaps, cleansers, drying cosmetics, high alcohol products, astringents and other irritants or keratolytic drugs
Contraindications
Contraindications:
- History of hypersensitivity, allergy or intolerance to this product or any of its components
Drug interactions
Avoid use of medicated or abrasive soaps, cleansers, cosmetics with drying effects, products with high concentration of alcohol, astringent & other irritants or keratolytic drugs; also avoid concomitant use of medications with photosensitizing effects.
Food interactions
No food interaction found/established.
Use in pregnancy
Use in Pregnancy: Category C; contains teratogen tretinoin which may cause embryo-fetal death, altered fetal growth, congenital malformations and potential neurologic deficits; use only if potential benefit justifies potential risk to fetus.
Use in lactation
Use in Lactation: Corticosteroids appear in human milk when systemically administered; it is not known whether topical application could result in sufficient systemic absorption; caution should be exercised.
Pediatric use
Safety and efficacy in pediatric patients have not been established.
Geriatric use
No specific data for elderly.
Renal / hepatic impairment
No specific data for renal or hepatic impairment.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Store in a cool & dry place, protected from light; do not freeze; keep out of reach of children.
Chemical structure
Hydroquinone + Tretinoin + Mometasone Furoate