Generic
Isradipine
1 brands available in the market
At a glance
Isradipine is a dihydropyridine calcium channel blocker used for the treatment of hypertension.
Description
Isradipine is a dihydropyridine Ca channel blocker. It prevents Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation. It is used for the treatment of hypertension.
Indications
- Hypertension
Therapeutic class
Other Anti-anginal & Anti-ischaemic drugs
Pharmacological class
Dihydropyridine Calcium Channel Blocker
Pharmacology
Isradipine is a dihydropyridine Ca channel blocker. It prevents Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.
Mechanism of action
Prevents Ca ions from entering slow channels to relax vascular smooth muscle and cause coronary vasodilation.
Dosage
Adult Dose (Oral):
- Initial: 2.5 mg twice daily; increase if necessary after 3-4 weeks to 5 mg twice daily, or 10 mg twice daily as required
- Elderly: Initially: 1.25 mg twice daily; Maintenance: 2.5 or 5 mg once daily
- Hepatic impairment: Initially: 1.25 mg twice daily; Maintenance: 2.5 or 5 mg once daily
Child Dose: Safety and efficacy not established
Administration
May be taken with or without food; follow dose and duration as advised by your doctor.
Missed dose
If you miss a dose, take it as soon as possible; if it is almost time for your next dose, skip the missed dose and go back to regular schedule; do not double the dose.
Side effects
>10%: Headache (2-22%)
1-10%: Edema (1-9%), Dizziness (2-8%), Palpitation (1-5%), Flushing (1-5%), Tachycardia (1-3%), Chest pain (2-3%), Rash (2%), Nausea (1-5%), Vomiting (<1%), Diarrhea (≤3%), Weakness (<1%), Dyspnea (1-3%), Urinary frequency (1-3%)
<1%: Drug-induced gingival hyperplasia, Angioedema, Drowsiness, Hyperhidrosis, Leg pain, Nasal congestion, Drug fever, Dysuria, Impotence, Pruritus, Urticaria, Weight gain, Myocardial infarction
Precautions & warnings
Precautions:
- Hypotension, poor cardiac reserve, heart failure
- Pregnancy
- Lactation: not known if excreted into breast milk
Contraindications
Contraindications:
- Cardiogenic shock
- Recent MI or acute unstable angina
- Severe aortic stenosis
- Lactation
- Porphyria
Drug interactions
Drug Interactions:
- Concurrent administration with enzyme-inducing drugs (rifampicin, phenobarbital, carbamazepine) reduces plasma concentrations of isradipine
- Increased bioavailability with cimetidine
- May increase serum levels with CYP3A4 inhibitors (macrolides, HIV protease inhibitors, azole antifungals, delavirdine)
Food interactions
No food interaction found/established.
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Use in lactation
Use in Lactation: It is not known if isradipine is excreted into breast milk; caution required.
Pediatric use
Safety and efficacy not established in pediatric patients.
Geriatric use
Elderly: Initially 1.25 mg twice daily; Maintenance 2.5 or 5 mg once daily.
Renal / hepatic impairment
Renal Impairment: No specific data; caution required.
Hepatic Impairment: Initially 1.25 mg twice daily; Maintenance 2.5 or 5 mg once daily.
Overdose effects
Overdose: Severe hypotension, tachycardia, bradycardia may occur; symptomatic supportive treatment; gastric lavage; cardiovascular support.
Storage conditions
Store in a cool and dry place, away from light & moisture; keep out of reach of children.
Chemical structure
Isradipine