At a glance
Isradipine is a dihydropyridine calcium channel blocker used for the treatment of hypertension.
Indications
- Hypertension
Pharmacology
Isradipine is a dihydropyridine Ca channel blocker. It prevents Ca ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.
Dosage
Adult Dose (Oral):
- Initial: 2.5 mg twice daily; increase if necessary after 3-4 weeks to 5 mg twice daily, or 10 mg twice daily as required
- Elderly: Initially: 1.25 mg twice daily; Maintenance: 2.5 or 5 mg once daily
- Hepatic impairment: Initially: 1.25 mg twice daily; Maintenance: 2.5 or 5 mg once daily
Child Dose: Safety and efficacy not established
Side effects
>10%: Headache (2-22%)
1-10%: Edema (1-9%), Dizziness (2-8%), Palpitation (1-5%), Flushing (1-5%), Tachycardia (1-3%), Chest pain (2-3%), Rash (2%), Nausea (1-5%), Vomiting (<1%), Diarrhea (≤3%), Weakness (<1%), Dyspnea (1-3%), Urinary frequency (1-3%)
<1%: Drug-induced gingival hyperplasia, Angioedema, Drowsiness, Hyperhidrosis, Leg pain, Nasal congestion, Drug fever, Dysuria, Impotence, Pruritus, Urticaria, Weight gain, Myocardial infarction
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Precautions & warnings
Precautions:
- Hypotension, poor cardiac reserve, heart failure
- Pregnancy
- Lactation: not known if excreted into breast milk
Overdose effects
Overdose: Severe hypotension, tachycardia, bradycardia may occur; symptomatic supportive treatment; gastric lavage; cardiovascular support.
Storage conditions
Store in a cool and dry place, away from light & moisture; keep out of reach of children.