Generic
Lymecycline
1 brands available in the market
At a glance
Lymecycline is an antibiotic used for the treatment of bacterial infections. It is effective for lung, urinary tract, eye, skin infections, acne, and sexually transmitted diseases.
Description
Lymecycline is a tetracycline derivative that is approximately 5000 times more soluble than tetracycline base and is absorbed by an active transport process across the intestinal wall. It binds to the 30S ribosome subunit, blocking the access of bacterial aminoacyl-tRNA to the mRNA-ribosome complex, preventing peptide chain elongation in protein synthesis.
Indications
- Acne
- Ear, nose, and throat infections
- Acute exacerbation of chronic bronchitis
- Gastrointestinal infections
- Urinary tract infections
- Non-gonococcal urethritis
- Trachoma
- Rickettsial fever
- Soft tissue infections
Therapeutic class
Tetracycline Group of Drugs
Pharmacological class
Tetracycline Antibiotic
Pharmacology
Lymecycline binds to the 30S ribosomal subunit to block aminoacyl-tRNA access to the mRNA-ribosome complex, inhibiting bacterial protein synthesis and bacterial growth.
Mechanism of action
Inhibits bacterial protein synthesis to stop bacterial growth.
Dosage
Adult Dose (Oral):
- Acne (chronic): 1 capsule daily, for at least 8 weeks
- Other infections: 1 capsule twice daily
- Higher doses: 3-4 capsules over 24 hours
Children (12 years+): Adult dose
Administration
- Swallow capsule whole; do not chew, crush or break
- Take with a glass of water
- Take on an empty stomach (1 hour before or 2 hours after food)
Missed dose
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Vomiting
- Nausea
- Diarrhea
- Photosensitivity
Precautions & warnings
- Caution when driving or doing activities requiring concentration (may cause dizziness or drowsiness)
- Discontinue and inform doctor if rash, itching, facial swelling, or breathing difficulty occurs
- Inform doctor if diarrhea persists or blood in stools
- Consult doctor during pregnancy and lactation
Contraindications
- Hypersensitivity to tetracyclines
- Concurrent treatment with oral retinoids
- Pregnancy and lactation
- Children under 12 years
Drug interactions
- Oral retinoids (risk of intracranial HTN)
- Iron preparations and antacids reduce absorption
- Increased risk of hemorrhage with coumarin anticoagulants
- Decreased digestive absorption with didanosine
Food interactions
Alcohol consumption with Lymecycline is safe.
Use in pregnancy
Use in Pregnancy: Lymecycline is unsafe during pregnancy; definite evidence of risk to the fetus (bone and tooth discoloration, enamel hypoplasia).
Use in lactation
Use in Lactation: No information on use during breastfeeding; consult your doctor.
Pediatric use
Not recommended for children under 12 years (effects on bone and tooth development).
Geriatric use
No specific dose adjustment required in elderly.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; overt renal insufficiency is contraindicated; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; care should be exercised in hepatic impairment.
Overdose effects
No specific treatment for overdose; gastric lavage; supportive measures and high fluid intake.
Storage conditions
Store at temperature not exceeding 30°C in a dry place, protected from light; keep out of reach of children.
Chemical structure
Lymecycline