Grape extract [Mahadrakkharist]

Introduction: Mahadrakkharist is a classical polyherbal ayurvedic preparation rich in resveratrol and proanthocyanidins (PCOs). It is effective in Chronic Obstructive Pulmonary Diseases. Vitis vinifera (grape) is the principal herb.

How it works: Proanthocyanidins protect cell membranes and inhibit the release of inflammatory chemicals (histamine and prostaglandins). Resveratrol has antioxidant and anti-inflammatory properties that may protect against COPD and asthma. It inhibits LDL oxidation, smooth muscle cell proliferation and platelet aggregation.

Important Information: Adults: 3-4 teaspoonfuls (15-20 ml) twice daily after meal for 4-8 weeks. Children under 12: 1-2 teaspoonfuls (5-10 ml) twice daily after meal.

• Chronic Obstructive Pulmonary Disease (COPD)
• Asthma - both allergic and cardiac asthma
• Pulmonary fibrosis
• Pulmonary tuberculosis

Herbal and Nutraceuticals

Ayurvedic Herbal Preparation

Grapes contain beneficial bioflavonoid-like ingredients called proanthocyanidins (PCOs or OPCs). Proanthocyanidins protect cell membranes by neutralizing harmful free radicals called lipid peroxides. PCOs may strengthen capillary walls and skin. It inhibits the release of inflammatory chemicals, such as histamine and prostaglandins. PCOs have been used in allergies and asthma because of their ability to slow histamine release from mast cells. Resveratrol has antioxidant and anti-inflammatory properties that may protect against COPD and asthma. It inhibits LDL oxidation, smooth muscle cell proliferation and platelet aggregation.

Proanthocyanidins protect cell membranes and Resveratrol reduces inflammation, improving respiratory health.

Adults and above 12 years:

• 3-4 teaspoonfuls (15-20 ml) twice daily after meal
• For 4-8 weeks or as directed by the physician

Children under 12 years:

• 1-2 teaspoonfuls (5-10 ml) twice daily after meal

* Use as directed by the registered physician

Oral syrup. Take after meals. Take in the dose and duration as advised by your doctor.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.

Side Effects:

• There are no side effects associated with the use in therapeutic doses
• In very rare cases, stomach pain, headache and allergic reaction may occur

Precautions:

• Caution in hypertension, liver disease, alcohol dependence and diabetes
• Caution with anticoagulants (warfarin, aspirin), NSAIDs, ACE inhibitors and antiplatelet agents
• Probiotics should be taken 2 or more hours apart

Contraindications:

• No known contraindications

Drug Interactions:

• Anticoagulants (warfarin, aspirin, NSAIDs) may increase bleeding risk
• May affect efficacy of ACE inhibitors

Food Interactions: No interaction found/established.

Use in Pregnancy: Consult your doctor before use during pregnancy. No reports of adverse effects on fetal development.

Use in Lactation: Consult your doctor before use during lactation.

Pediatric Use: Dosage available for children under 12 years.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal & Hepatic Impairment: Caution in liver disease. No known restrictions in kidney disease.

Overdose: Overdose may cause stomach pain or gastrointestinal discomfort. Symptomatic treatment should be given.

Storage: Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Mahadrakkharist Syrup