Generic
Metamizol
3 brands available in the market
At a glance
Metamizol is a pain relieving, anti-inflammatory, and fever-reducing medicine used for pain relief and reducing fever. It works by inhibiting the synthesis of prostaglandins D and E.
Description
Metamizol is an NSAID that inhibits prostaglandin D and E synthesis to provide analgesic, anti-inflammatory, and antipyretic effects. It has the potential for causing agranulocytosis.
Indications
- Pain relief
- Inflammation relief
- Fever reduction
Therapeutic class
NSAIDs
Pharmacological class
Pyrazolone Derivative
Pharmacology
Metamizol inhibits prostaglandin D and E synthesis to reduce pain, inflammation, and fever.
Mechanism of action
Relieves pain, inflammation, and fever by inhibiting prostaglandin synthesis.
Dosage
Adult Dose (Parenteral):
- 16-31 kg: 250 mg (0.5 mL)
- 32-46 kg: 500 mg (1 mL)
- 47-62 kg: 500-750 mg (1-1.5 mL)
- >63 kg: 750-1000 mg (1.5-2 mL)
- Repeat every 6-8 hours; max 4 g/day
- Parenteral use not more than 3 days
Administration
- Swallow tablet whole; do not chew, crush or break
- May be taken with or without food, but at a fixed time is preferable
Missed dose
If you miss a dose, take it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Common Side Effects:
- Vomiting
- Abdominal pain
- Nausea
- Diarrhea
- Agranulocytosis (rare but serious)
Precautions & warnings
- Caution when driving or doing activities requiring concentration (may cause dizziness, drowsiness, visual disturbances)
- Long-term use may cause stomach bleeding and kidney problems
- Monitor kidney function, liver function, and blood components regularly
- Avoid alcohol
Contraindications
- Hypersensitivity to ingredients
- Renal failure, pyelonephritis, glomerulonephritis
- Inhibition of hematopoiesis (neutropenia, agranulocytosis)
- Liver failure
- Anemia (including hereditary hemolytic anemia)
- Leukopenia
- Propensity to bronchospasm
- Optic neuritis
- Myasthenia gravis
Drug interactions
No significant drug interactions known.
Food interactions
Alcohol consumption with Metamizol is unsafe.
Use in pregnancy
Use in Pregnancy: Metamizol may be unsafe during pregnancy; animal studies have shown harmful effects on the fetus. Consult your doctor.
Use in lactation
Use in Lactation: No information available on use during lactation; consult your doctor.
Pediatric use
Not recommended for children under 18 years.
Geriatric use
Elderly may require dose adjustment (based on renal function).
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed; not recommended in severe kidney disease.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed; not recommended in severe liver disease.
Overdose effects
Overdose may cause nausea, abdominal pain, diarrhea; symptomatic treatment.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.
Chemical structure
Metamizol