Generic
Miconazole 2% Oral Gel
25 brands available in the market
At a glance
Miconazole 2% Oral Gel is an antifungal medicine used for the treatment of oral and gastrointestinal candidiasis.
Description
Miconazole 2% Oral Gel is an antifungal medication that inhibits ergosterol synthesis, damaging the fungal cell wall membrane and increasing its permeability. It allows essential constituents of fungal cells to leak out, ultimately leading to fungal cell death.
Indications
- Oral candidiasis (oral thrush)
- Gastrointestinal candidiasis
- Eradication of fungal colonization in the mouth and gastrointestinal tract
- Super infections due to gram-positive bacteria
Pharmacological class
Imidazole Antifungal
Pharmacology
Miconazole inhibits a demethylation step in ergosterol biosynthesis. Ergosterol is the main sterol in yeast and fungi. Disruption in ergosterol production creates holes in the fungal cell membrane, allowing essential constituents to leak out and causing fungal cell death.
Mechanism of action
Prevents fungal growth by destroying the fungal cell wall.
Dosage
Oral Gel Dose:
- Oropharyngeal Candidiasis: Adults and children ≥2 years: 2.5 ml (1/2 spoon) 4 times daily; Infants 4-24 months: 1.25 ml (1/4 spoon) 4 times daily
- Gastrointestinal Candidiasis: 20 mg/kg/day (in 4 divided doses); Max: 250 mg (10 ml) 4 times daily
- Continue treatment for at least 1 week after symptoms resolve
Administration
- Use after meals
- Apply a small amount to the affected area with a clean finger
- Keep gel in contact with the affected area as long as possible
- Remove dental prosthesis at night and brush with gel
Missed dose
If you miss a dose, apply it as soon as you remember; skip if it's almost time for the next dose; do not double the dose.
Drug interactions
- Warfarin: Increased anticoagulant effect
- Oral Hypoglycemics (sulfonylureas): Increased effect
- Phenytoin: Delayed metabolism, may precipitate toxicity
- Cyclosporine: May precipitate toxicity
- Astemizole, Cisapride, Terfenadine: Risk of cardiac arrhythmia (potentially fatal)
Food interactions
Food interaction not found.
Contraindications
- Hypersensitivity to components
- Liver dysfunction
Side effects
Side Effects:
- Nausea and vomiting (occasionally)
- Diarrhea with long-term use
- Allergic reactions (rare)
Use in pregnancy
Use in Pregnancy: Possibly unsafe. Limited human studies; animal studies show harmful effects. Your doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safe. The drug does not pass into breastmilk in significant amounts.
Precautions & warnings
- For external use only (oral gel is for oral use)
- In infants and young children, ensure the gel does not obstruct the throat
- Caution in pregnancy and lactation
Pediatric use
Pediatric dose established: 4-24 months: 1.25 ml 4 times daily; ≥2 years: 2.5 ml 4 times daily
Geriatric use
No specific dose adjustment for elderly (adult dose applies)
Renal / hepatic impairment
Renal Impairment: No interaction found.
Hepatic Impairment: No interaction found.
Overdose effects
Accidental overdosage may cause vomiting and diarrhea. Symptomatic and supportive treatment.
Therapeutic class
Other Antifungal Preparations
Storage conditions
Keep in a dry place away from light and heat. Keep out of reach of children.
Chemical structure
Miconazole 2% Oral Gel