Generic
Naphazoline Nitrate 0.005% + Zinc Sulphate 0.02% Eye prep
3 brands available in the market
At a glance
Naphazoline Nitrate 0.005% + Zinc Sulphate 0.02% Eye prep is used as a conjunctival decongestant. It relieves eye irritation, redness and burning caused by dry eyes and helps in bacterial and viral conjunctivitis.
Description
Naphazoline is an imidazoline derivative sympathomimetic amine that produces vasoconstriction by stimulating alpha-adrenergic receptors in arterioles of conjunctiva and nasal mucosa. Zinc sulphate is an astringent that helps reduce tissue swelling and inflammation.
Indications
- Conjunctival decongestant
- Acute and chronic non-infectious conjunctivitis
- Nonspecific conjunctival irritation
- Bacterial and viral conjunctivitis
- Irrigation of tear ducts
Therapeutic class
Ophthalmic Decongestant & Astringent
Pharmacological class
Vasoconstrictor + Astringent
Pharmacology
Naphazoline stimulates alpha-adrenergic receptors to produce vasoconstriction and reduce conjunctival redness and swelling. Zinc sulphate acts as an astringent to reduce tissue swelling and inflammation.
Mechanism of action
Relieves eye redness, irritation and dry eye discomfort.
Dosage
Adult Dose (Eye Drops):
- 1-2 drops in conjunctival sac, 3-4 times daily
Pediatric Dose:
- 1 drop in conjunctival sac, 3-4 times daily
Administration
- Do not touch dropper tip to eye
- Instill in lower eyelid
- Wipe off extra liquid
Missed dose
If you miss a dose, use it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Side Effects:
- Mydriasis
- Slight increase in intraocular pressure (isolated cases)
- Slight and transient burning sensation after instillation
- Rebound redness with long-term use
- Rare systemic CV effects (hypertension, arrhythmia)
- Nonspecific fatigue
Precautions & warnings
- Caution in predisposition to glaucoma, hypertension, CV diseases, pheochromocytoma, aneurysm, hyperglycemia and hyperthyroidism
- Rebound congestion may occur with prolonged use
Contraindications
- Hypersensitivity
- Narrow-angle glaucoma
- Dry eye and especially keratoconjunctivitis sicca (Sjogren's syndrome)
- Must not be used in infants
Drug interactions
No known interactions.
Food interactions
No food interactions (eye drops).
Use in pregnancy
Use in Pregnancy: Caution during pregnancy; consult doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Unknown if distributed in breast milk; use with caution.
Pediatric use
Must not be used in infants.
Geriatric use
Elderly may require dose adjustment.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
Overdose may cause systemic CV effects; symptomatic treatment.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.
Chemical structure
Naphazoline + Zinc Sulphate Eye Drops