Generic
Neomycin Sulphate 0.35% + Polymixin B Sulphate 0.127% + Prednisolone 0.5% Eye prep
2 brands available in the market
At a glance
Neomycin Sulphate + Polymixin B Sulphate + Prednisolone Eye prep is used for bacterial ocular infections and steroid-responsive inflammatory eye conditions.
Description
Neomycin binds to 30S ribosomal subunit to inhibit bacterial protein synthesis. Prednisolone decreases inflammation by inhibition of polymorphonuclear leukocyte migration and reversal of increased capillary permeability. Polymyxin B causes leakage of bacterial membrane to produce bactericidal effect.
Indications
- Bacterial ocular infection
- Steroid-responsive inflammatory eye conditions
- Conjunctivitis
- Keratitis
Therapeutic class
Ophthalmic Antibiotic & Steroid
Pharmacological class
Antibiotic + Corticosteroid Combination
Pharmacology
Neomycin binds to 30S ribosomal subunit to inhibit bacterial protein synthesis. Prednisolone inhibits polymorphonuclear leukocyte migration and reverses capillary permeability to reduce inflammation and suppresses immune system. Polymyxin B causes bacterial membrane leakage to produce bactericidal effect.
Mechanism of action
Treats infection by inhibiting bacterial protein synthesis and reduces inflammation.
Dosage
Adult Dose (Eye Drops):
- 1-2 drops every 3-4 hours; acute infections may require every 30 minutes; reduce frequency as infection is controlled
- For lid treatment: 1-2 drops every 3-4 hours, close eye and rub excess on lids
Pediatric Dose: 1-2 drops 2-4 times daily
Administration
- Do not touch dropper tip to eye
- Instill in lower eyelid
- Wipe off extra liquid
Missed dose
If you miss a dose, use it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Side Effects:
- Elevation of intraocular pressure (glaucoma and optic nerve damage)
- Posterior subcapsular cataract formation
- Delayed wound healing
- Fungal and viral infections of cornea (with long-term steroid use)
Precautions & warnings
- Prolonged corticosteroid use may result in optic nerve damage and vision defects
- Monitor intraocular pressure regularly with prolonged use
- Risk of fungal and viral infections
Contraindications
- Epithelial herpes simplex keratitis
- Vaccinia, varicella
- Viral diseases of cornea and conjunctiva
- Mycobacterial infection of eye
- Fungal diseases of ocular structures
- Hypersensitivity
- After uncomplicated removal of corneal foreign body
Drug interactions
- Synergistic effects with penicillins
- Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs
- May decrease absorption of digoxin and methotrexate
- May increase effects of oral anticoagulants
Food interactions
No food interactions (eye drops).
Use in pregnancy
Use in Pregnancy: Safety not established; consult doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Unknown if excreted in breast milk; consult doctor.
Pediatric use
Dose established for children.
Geriatric use
Elderly may require dose adjustment.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
Limited information on overdose; symptomatic treatment.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.
Chemical structure
Neomycin + Polymyxin + Prednisolone Eye Drops