Olmesartan Medoxomil

Olmesartan Medoxomil is a medicine used to treat high blood pressure and heart failure. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. Olmesartan Medoxomil can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the maximum benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This is a widely used medicine and is considered safe for long-term use. Making some changes in your lifestyle will also help lower your blood pressure. These may include regular exercise, losing weight, smoking cessation, reducing alcohol intake, and reducing the amount of salt in your diet as advised by your doctor. This medicine is tolerated well by most patients and has few side effects. Dizziness, particularly after the first dose, is known to occur in some people. This may be associated with headache. Let your doctor know if these side effects bother you or do not go away. No weight gain has been seen with the regular use of this medicine. Before taking this medicine, let your doctor know if you have any kidney or liver problems. Pregnant or breastfeeding mothers should not take this medicine. Your doctor may check your kidney function, blood pressure and potassium levels in your blood at regular intervals while you are taking this medicine. Olmesartan Medoxomil is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.

• Hypertension (high blood pressure) • Heart failure • Prevention of heart attack and stroke

Olmesartan is a selective and competitive angiotensin II Type 1 (AT1) receptor antagonist that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. As a result, olmesartan relaxes blood vessels, hence lowering BP and increases blood supply and oxygen to the heart.

Adult Dose: Oral Hypertension Adult: Initial: 10-20 mg once daily may then be increased up to max 40 mg once daily if needed. Elderly: No dosage adjustment needed. Hepatic impairment: Moderate: Initial: 10 mg once daily may increase up to max 20 mg once daily. Child Dose: Oral Hypertension Child: 6-16 yr 35 kg: 20 mg once daily. Doses may be doubled once if necessary after 2 wk. dosage range: 20-40 mg/day Renal Dose: Renal impairment: Mild to moderate (CrCl: 20-60 mL/min): Max: 20 mg once daily.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Olmesartan Medoxomil may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Olmesartan Medoxomil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Cough • Diarrhea • Dizziness • Flu-like symptoms • Headache • Indigestion • Nausea • Runny nose • Sore throat • Stomach pain

[UNSAFE] Olmesartan Medoxomil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Take it at the same time every day to help you remember to take it. It can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time. Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood. Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor. It may increase the level of potassium in the blood. Avoid taking potassium supplements and potassium-rich foods such as banana fruit juice, coconut water, and broccoli. Do not take Olmesartan Medoxomil if you are pregnant or breastfeeding. Do not stop taking it suddenly without talking to your doctor.

Pregnancy (2nd and 3rd trimesters); biliary obstruction.

Increased risk of hyperkalaemia w/ ACE inhibitors, K-sparing diuretics, K salts or K supplements and drugs that may increase serum K (e.g. ciclosporin, eplerenone). May potentiate BP lowering effects w/ other antihypertensives. May decrease glomerular filtration w/ NSAIDs which can cause acute renal failure. May increase serum concentrations and toxicity of lithium.

[UNSAFE] Olmesartan Medoxomil may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Olmesartan Medoxomil is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Olmesartan Medoxomil is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Olmesartan Medoxomil should be used with caution in patients with severe kidney disease. Dose adjustment of Olmesartan Medoxomil may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment. [CAUTION] Olmesartan Medoxomil should be used with caution in patients with severe liver disease. Dose adjustment of Olmesartan Medoxomil may be needed. Please consult your doctor. No dose adjustment is recommended in patients with mild liver disease.

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