Generic
Oxyphenonium Bromide
5 brands available in the market
At a glance
Oxyphenonium Bromide is an anticholinergic used for gastrointestinal spasm and hypermotility, peptic ulcer, biliary tract and urinary tract pain and spasm.
Description
Oxyphenonium is an anticholinergic drug that reduces the effect of acetylcholine by blocking receptors on smooth muscle. It also has a direct relaxing effect on smooth muscle. It inhibits gastrointestinal propulsive motility, decreases gastric acid secretion and controls pharyngeal, tracheal and bronchial secretions.
Indications
- Gastrointestinal spasm and hypermotility
- Cardiospasm, esophagospasm
- Gastroduodenitis
- Spastic constipation
- Pylorospasm
- Peptic ulcer
- Biliary tract pain and spasm
- Urinary tract pain and spasm
Therapeutic class
Anticholinergics (Antimuscarinics)/Anti-spasmodics
Pharmacological class
Anticholinergic
Pharmacology
Oxyphenonium blocks muscarinic receptors of acetylcholine to relax smooth muscle and inhibits gastrointestinal propulsive motility to relieve spasm.
Mechanism of action
Relieves gastrointestinal and urinary tract spasm by relaxing smooth muscle.
Dosage
Adult Dose (Oral):
- 10 mg (2 tablets) 4 times daily for several days
- Dosage may be reduced based on response
Administration
- Swallow tablet whole; do not chew, crush or break
- Take at the same time each day
Missed dose
If you miss a dose, take it as soon as you remember; skip if it's almost time for next dose; do not double the dose.
Side effects
Common Side Effects:
- Dry mouth
- Headache
- Palpitations
- Constipation
- Difficulty in urination
- Dilatation of pupil
- Dry skin
- Excessive thirst
- Flushing
- Increased heart rate
- Loss of accommodation
- Photophobia
- Reduced bronchial secretion
Precautions & warnings
- Caution in children, elderly, benign prostatic hyperplasia, acute MI, cardiac failure, hypertension, thyrotoxicosis, pregnancy and lactation, fever, angle-closure glaucoma
- May impair ability to drive or operate machinery
Contraindications
- Glaucoma
- Obstructive uropathy
- Obstructive disease of GI tract
- Intestinal atony of elderly or debilitated patient
- Unstable cardiovascular status in acute hemorrhage
- Severe ulcerative colitis
- Toxic megacolon
- Myasthenia gravis
- Hypersensitivity
Drug interactions
- Reduced gastric motility interferes with absorption of other drugs
- Effects potentiated by other antimuscarinics (amantadine, some antihistamines, phenothiazines, TCAs)
Food interactions
Safety with alcohol not known; consult doctor.
Use in pregnancy
Use in Pregnancy: Oxyphenonium may be unsafe during pregnancy; animal studies show adverse effects; use only if potential benefit justifies risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Caution during breastfeeding; hold breastfeeding until treatment is completed.
Pediatric use
Caution in children.
Geriatric use
Caution in elderly.
Renal / hepatic impairment
Renal Impairment: Limited information; consult doctor.
Hepatic Impairment: Limited information; consult doctor.
Overdose effects
Overdose: Treatment same as for atropine overdosage.
Storage conditions
Store below 30°C, away from light & moisture; keep out of reach of children.
Chemical structure
Oxyphenonium Bromide