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At a glance

Oxyphenonium Bromide is an anticholinergic used for gastrointestinal spasm and hypermotility, peptic ulcer, biliary tract and urinary tract pain and spasm.

Indications
  • Gastrointestinal spasm and hypermotility
  • Cardiospasm, esophagospasm
  • Gastroduodenitis
  • Spastic constipation
  • Pylorospasm
  • Peptic ulcer
  • Biliary tract pain and spasm
  • Urinary tract pain and spasm
Pharmacology

Oxyphenonium blocks muscarinic receptors of acetylcholine to relax smooth muscle and inhibits gastrointestinal propulsive motility to relieve spasm.

Dosage

Adult Dose (Oral):

  • 10 mg (2 tablets) 4 times daily for several days
  • Dosage may be reduced based on response
Side effects

Common Side Effects:

  • Dry mouth
  • Headache
  • Palpitations
  • Constipation
  • Difficulty in urination
  • Dilatation of pupil
  • Dry skin
  • Excessive thirst
  • Flushing
  • Increased heart rate
  • Loss of accommodation
  • Photophobia
  • Reduced bronchial secretion
Use in pregnancy

Use in Pregnancy: Oxyphenonium may be unsafe during pregnancy; animal studies show adverse effects; use only if potential benefit justifies risk.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in children, elderly, benign prostatic hyperplasia, acute MI, cardiac failure, hypertension, thyrotoxicosis, pregnancy and lactation, fever, angle-closure glaucoma
  • May impair ability to drive or operate machinery
Overdose effects

Overdose: Treatment same as for atropine overdosage.

Storage conditions

Store below 30°C, away from light & moisture; keep out of reach of children.

Oxyphenonium Bromide — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.