Perindopril Erbumine

Perindopril Erbumine belongs to a group of medicines known as angiotensin converting enzyme (ACE) inhibitor. It is widely used to treat high blood pressure and heart failure and may be prescribed after a heart attack. It also lowers the chances of having a heart attack or stroke. Perindopril Erbumine can be prescribed either alone or in combination with other medicines. It should be taken on an empty stomach. This medicine should be taken at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or even if your blood pressure is controlled. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This medicine is considered safe for long-term use. Making some changes in your lifestyle will also help lower your blood pressure. These may include regular exercise, losing weight, smoking cessation, reducing alcohol intake, and reducing the amount of salt in your diet as advised by your doctor. The most common side effects of this medicine include feeling dizzy or drowsy, headache, dry cough, fatigue, nausea, vomiting, diarrhea, stomach pain, and low blood pressure. Most of these are temporary and resolve with time. Talk to your doctor if any of the side effects bother you or do not go away. Before taking this medicine, let your doctor know if you have any kidney or liver problems. Pregnant or breastfeeding mothers should also consult their doctor before taking it. Your doctor may check your kidney function, blood pressure and potassium levels in your blood at regular intervals while you are taking this medicine. Perindopril Erbumine is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.

• Hypertension (high blood pressure) • Prevention of heart attack and stroke • Heart failure

Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances.

Adult Dose: Oral Adult Hypertension 4-8 mg PO qDay or divided q12hr Maximum: 16 mg/day PO divided q12hr Stable Coronary Artery Disease (CAD) 4 mg PO qDay for 2 weeks, THEN increase as tolerated to 8 mg/day PO divided q12hr Reduce risk of cardiovascular mortality or MI in patients with stable CAD Heart Failure 2 mg PO qDay initially to maximum 8-16 mg PO qDay Elderly: Initially, 2 mg once daily. Dose may be increased to max 8 mg Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <15 2 mg on dialysis days. 15-30 2 mg on alternate days. 30-60 2 mg

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perindopril Erbumine is to be taken empty stomach.

If you miss a dose of Perindopril Erbumine, skip it and continue with your normal schedule. Do not double the dose.

Common: • Decreased blood pressure • Cough • Increased potassium level in blood • Fatigue • Weakness • Dizziness

[UNSAFE] Perindopril Erbumine may cause side effects which could affect your ability to drive. Perindopril Erbumine usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in some patients. This may affect your driving ability. Perindopril Erbumine can make you feel dizzy for the first few days, so rise slowly if you have been sitting or lying down. You can also prefer taking it at bedtime to avoid dizziness throughout the day. Let your doctor know about any cough, or throat irritation that does not go away. It may increase the level of potassium in blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

History of angioedema related to previous ACE inhibitor treatment. Pregnancy (2nd/3rd trimesters).

May enhance hypotensive effect w/ diuretics. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics, and other drugs (e.g. ciclosporin, heparin, indometacin). May increase serum levels and toxicity of lithium. Antihypertensive effect may be reduced by aspirin or other NSAIDs. Coadministration w/ NSAIDs may also increase the risk of renal impairment. Increased risk of hypoglycaemia w/ antidiabetic agents. Rarely, nitritoid reactions occur w/ concomitant use of gold (sodium aurothiomalate). Potentially Fatal: Increased risk of hypotension, hyperkalaemia and changes in renal function (including acute renal failure) w/ aliskiren in patients w/ diabetes or renal impairment.

[UNSAFE] Perindopril Erbumine may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Perindopril Erbumine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[SAFE IF PRESCRIBED] Perindopril Erbumine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Perindopril Erbumine should be used with caution in patients with kidney disease. Dose adjustment of Perindopril Erbumine may be needed. Please consult your doctor. Caution should be advised in patients with renal impairment. [CAUTION] Perindopril Erbumine should be used with caution in patients with liver disease. Dose adjustment of Perindopril Erbumine may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.

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