৳ 28/unit
Pack: ৳ 840
৳ 28/unit
Pack: ৳ 840
At a glance
Perindopril Erbumine is an ACE inhibitor used for the treatment of high blood pressure, heart failure, and may be prescribed after a heart attack. It lowers the chances of having a heart attack or stroke and relaxes blood vessels so that blood flows more smoothly.
Indications
- Hypertension (high blood pressure)
- Prevention of heart attack and stroke
- Heart failure
Pharmacology
Perindopril inhibits ACE, reducing angiotensin II production, resulting in decreased vasoconstriction and aldosterone secretion. It also decreases the degradation of bradykinin, which contributes to vasodilation.
Dosage
Adult Dose (Oral):
- Hypertension: 4-8 mg once daily or divided q12hr; max 16 mg/day
- Stable CAD: 4 mg once daily for 2 weeks, then increase to 8 mg/day
- Heart failure: 2 mg once daily initially, max 8-16 mg/day
- Elderly: Initially 2 mg once daily; may increase to max 8 mg
- Renal impairment: CrCl <15 mL/min: 2 mg on dialysis days; 15-30: 2 mg on alternate days; 30-60: 2 mg
Side effects
Common Side Effects:
- Decreased blood pressure
- Cough
- Increased potassium level in blood
- Fatigue
- Weakness
- Dizziness
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby. Contraindicated in 2nd and 3rd trimesters.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if dizziness or weakness occurs
- May cause dizziness for the first few days; rise slowly from sitting or lying position
- Taking at bedtime may help avoid daytime dizziness
- Inform doctor if cough or throat irritation persists
- Avoid potassium supplements and potassium-rich foods
- Do not use during pregnancy and lactation
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store in a dry place; keep out of reach of children.