Generic
Pipecuronium bromide
2 brands available in the market
At a glance
Pipecuronium bromide is a muscle relaxant used with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It works by blocking transmission of impulses from nerves to muscles.
Description
Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker. It competes with acetylcholine at the neuromuscular junction, producing non-depolarizing blockade and preventing active muscle contraction. It does not have significant cardiovascular adverse effects or histamine-related effects.
Indications
- Skeletal muscle relaxation during general anesthesia
- Facilitate endotracheal intubation
Therapeutic class
Neuromuscular blocker
Pharmacological class
Aminosteroidal Competitive Neuromuscular Blocker
Pharmacology
Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker that competes with acetylcholine at the neuromuscular junction. It produces non-depolarizing blockade and prevents active muscle contraction. It has no significant cardiovascular or histamine-related effects.
Mechanism of action
Relaxes muscles by blocking acetylcholine receptors at the neuromuscular junction.
Dosage
Adult Dose (Intravenous):
- Muscle relaxant in general anesthesia: Initial dose 80-100 mcg/kg
- Subsequent doses: 10-20 mcg/kg
- After suxamethonium or high-risk patients: 50-60 mcg/kg
- Caesarean section initial dose: 35 mcg/kg
Administration
- Administered by healthcare professional as IV injection; do not self-administer
- Dose determined by anesthesia requirements
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects:
- Skin rash
- Increased saliva production
- Injection site reactions (pain, swelling, redness)
- High blood pressure
Precautions & warnings
- May affect driving ability; do not drive if drowsy or dizzy
- Caution with anticoagulants or drugs affecting blood clotting
Contraindications
- Hypersensitivity to pipecuronium bromide or any ingredient
Drug interactions
- Cholinesterases, long-term carbamazepine, phenytoin, corticosteroids: Antagonized action
- Lidocaine, quinidine, verapamil, aminoglycosides: Enhanced block
- Potentially fatal: Volatile inhalational anesthetics, ketamine (IV), antiarrhythmics, antibacterials, K-depleting diuretics, parenteral Mg salts: Enhanced effects
Food interactions
It is not known whether it is safe to consume alcohol with Pipecuronium bromide.
Use in pregnancy
Use in Pregnancy: Information regarding use during pregnancy is not available; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Information regarding use during breastfeeding is not available; consult your doctor.
Pediatric use
Safety not established in children; consult your doctor.
Geriatric use
Caution required in elderly patients; consult your doctor.
Renal / hepatic impairment
Renal Impairment: Limited information on use in kidney disease; consult your doctor.
Hepatic Impairment: Limited information on use in liver disease; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if overused.
Storage conditions
Store in a cool and dry place; keep out of reach of children.
Chemical structure
Pipecuronium Bromide