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At a glance

Pipecuronium bromide is a muscle relaxant used with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It works by blocking transmission of impulses from nerves to muscles.

Indications
  • Skeletal muscle relaxation during general anesthesia
  • Facilitate endotracheal intubation
Pharmacology

Pipecuronium bromide is an aminosteroidal competitive neuromuscular blocker that competes with acetylcholine at the neuromuscular junction. It produces non-depolarizing blockade and prevents active muscle contraction. It has no significant cardiovascular or histamine-related effects.

Dosage

Adult Dose (Intravenous):

  • Muscle relaxant in general anesthesia: Initial dose 80-100 mcg/kg
  • Subsequent doses: 10-20 mcg/kg
  • After suxamethonium or high-risk patients: 50-60 mcg/kg
  • Caesarean section initial dose: 35 mcg/kg
Side effects

Common Side Effects:

  • Skin rash
  • Increased saliva production
  • Injection site reactions (pain, swelling, redness)
  • High blood pressure
Use in pregnancy

Use in Pregnancy: Information regarding use during pregnancy is not available; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if drowsy or dizzy
  • Caution with anticoagulants or drugs affecting blood clotting
Overdose effects

No overdose information available; consult your doctor if overused.

Storage conditions

Store in a cool and dry place; keep out of reach of children.

Pipecuronium bromide — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.