Generic
Pneumococcal Polysaccharide Conjugated Vaccine
1 brands available in the market
At a glance
Pneumococcal Polysaccharide Conjugated Vaccine is used for prevention of invasive diseases caused by pneumococcal bacteria such as pneumonia, meningitis, blood infections, and ear infections. It helps develop immunity by initiating a mild infection.
Description
Pneumococcal Polysaccharide Conjugated Vaccine provides active immunization against pneumococcal disease. It works by stimulating production of endogenous antibodies against S. pneumoniae capsular polysaccharide antigens. The conjugated formulation provides enhanced immune response in children, especially those under 2 years where unconjugated polysaccharide vaccines are ineffective.
Indications
- Prevention of pneumococcal disease (pneumonia, meningitis, bacteremia, otitis media)
Therapeutic class
Vaccines, Anti-sera & Immunoglobulin
Pharmacological class
Pneumococcal Conjugated Vaccine
Pharmacology
Pneumococcal Polysaccharide Conjugated Vaccine stimulates active immune response against S. pneumoniae capsular polysaccharide antigens, producing endogenous antibodies. The conjugated formulation induces T-cell-dependent immune response, providing enhanced immunogenicity and immunologic memory in children.
Mechanism of action
Produces immunity by stimulating antibody production against pneumococcal antigens.
Dosage
Pediatric Dose (Intramuscular):
- 6 weeks-6 months (3-dose Primary): 1st dose at 2 months or 6 weeks, 3 doses with 1-month interval; Booster at least 6 months after last primary dose
- 2-dose Primary: 1st dose at 2 months, 2-month interval between 1st & 2nd dose
- 7-11 months (previously unvaccinated): 2 doses at least 1 month apart, 3rd dose in 2nd year
- 12 months-5 years (previously unvaccinated): 2 doses at least 2 months apart
- Pre-term infants (≥27 weeks gestation): 3 doses with 1st dose at 2 months, 1-month interval; Booster at least 6 months after last primary dose
Administration
- Given by doctor or nurse as intramuscular injection (usually in the upper arm muscle)
- Do not self-administer
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects:
- Injection site redness
- Sleepiness
- Irritation
- Loss of appetite
- Fever
- Allergic reaction
- Rash
- Pain
Precautions & warnings
- Delay vaccination in febrile illness (until recovery)
- Inform doctor if fever occurs; if >102°F or persists
- Consult doctor during pregnancy and lactation
Contraindications
- Hypersensitivity to any component of the vaccine
- Febrile illness, acute disease
- Anaphylactic reaction to a previous dose
- Severe primary immunodeficiency
Drug interactions
- Immunosuppressants: Adequate response may not be elicited
Food interactions
It is not known whether it is safe to consume alcohol with Pneumococcal Polysaccharide Conjugated Vaccine.
Use in pregnancy
Use in Pregnancy: Information regarding use during pregnancy is not available; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Information regarding use during breastfeeding is not available; consult your doctor.
Pediatric use
Indicated for children 6 weeks to 5 years; enhanced immune response in children under 2 years.
Geriatric use
Not applicable for elderly (pediatric vaccine).
Renal / hepatic impairment
Renal Impairment: Limited information on use in kidney disease; consult your doctor.
Hepatic Impairment: Limited information on use in liver disease; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if overused.
Storage conditions
Store refrigerated at 2-8°C; protect vials from light; do not freeze.
Chemical structure
Pneumococcal Polysaccharide Conjugated Vaccine