Generic
Pneumococcal Polysaccharide Vaccine 23 valent
1 brands available in the market
At a glance
Pneumococcal Polysaccharide Vaccine 23 valent is recommended for active immunization against pneumococcal disease in children aged from 2 years, adolescents, and adults. It contains 23 pneumococcal polysaccharide serotypes that account for approximately 90% of invasive pneumococcal disease types.
Description
The vaccine is prepared from purified pneumococcal capsular polysaccharide antigens derived from 23 serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, 33F. It stimulates active immune response against S. pneumoniae capsular antigens, producing endogenous antibodies.
Indications
- Active immunization against pneumococcal disease in children from 2 years, adolescents, and adults
Therapeutic class
Vaccines, Anti-sera & Immunoglobulin
Pharmacological class
23-valent Pneumococcal Polysaccharide Vaccine
Pharmacology
The vaccine is prepared from 23 pneumococcal capsular polysaccharide serotypes that account for approximately 90% of invasive pneumococcal disease types. It stimulates active immune response against S. pneumoniae capsular antigens, producing endogenous antibodies.
Mechanism of action
Produces immunity by stimulating antibody production against pneumococcal antigens.
Dosage
Primary Vaccination:
- Adults and children ≥2 years: Single dose of 0.5 mL (IM or SC)
- Not recommended in children <2 years
- Should be given at least 2 weeks before elective splenectomy, chemotherapy, or immunosuppressive treatment
- Avoid during chemotherapy/radiation therapy; at least 3 months after completion
Revaccination:
- Single dose 0.5 mL (IM or SC)
- Healthy adults: Not routinely revaccinated
- High-risk patients (asplenia, sickle cell disease): May be considered at 3 years
- Revaccination within 3 years not recommended (increased risk of adverse reactions)
Administration
- Administered as IM or SC injection in deltoid muscle or lateral mid-thigh
- May be given SC if patient has bleeding disorders
- Never inject intravascularly or intradermally
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects (>10%):
- Injection-site pain/soreness (60%)
- Injection-site swelling/induration (20.3%)
- Headache (17.6%)
- Injection-site erythema (16.4%)
- Asthenia and fatigue (13.2%)
- Myalgia (11.9%)
- Fever, rash, arthralgia, allergic reactions (rare)
Precautions & warnings
- Delay use in significant febrile illness or active infection
- Never inject intravascularly or intradermally
- Reduced antibody response in immunosuppressed patients
- Caution in pregnancy and lactation
- Do not stop required prophylactic antibiotics
- Epinephrine (adrenaline) should be available for anaphylactic reactions
Contraindications
- Allergy to any component of the vaccine
- Fever, acute infection, or chronic disease at acute stage
- Uncontrolled epilepsy or other progressive nervous system diseases
- Vaccination within previous 3 years (unless otherwise indicated)
Drug interactions
- Can be administered simultaneously with influenza vaccine (different needles and injection sites)
Food interactions
Not food-related; it is not known whether it is safe to consume alcohol.
Use in pregnancy
Use in Pregnancy: Animal studies insufficient; should not be used unless clearly necessary; consider potential risk to fetus.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Unknown if vaccine is excreted in human milk; caution required.
Pediatric use
Not recommended in children under 2 years (safety and efficacy not established; poor antibody response).
Geriatric use
Indicated for elderly (≥65 years); higher local and systemic reaction rates after revaccination.
Renal / hepatic impairment
Renal Impairment: Caution in severe renal dysfunction; consult your doctor.
Hepatic Impairment: Caution in severe hepatic dysfunction; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if overused.
Storage conditions
Store refrigerated at 2-8°C; protect vials from light; do not freeze.
Chemical structure
Pneumococcal Polysaccharide Vaccine 23 Valent