Generic
Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride
3 brands available in the market
At a glance
Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride is a colloidal solution volume expander used for prophylaxis of hypovolemia and shock, surgery (hemorrhagic shock), injuries (traumatic shock), burns, and therapeutic dilution of blood.
Description
The colloidal solution containing hydroxyethyl starch is a volume expander that increases intravascular oncotic pressure and restores plasma volume. It reduces blood viscosity and improves microcirculation. The 60g/100mL hydroxyethyl starch solution with sodium chloride maintains electrolyte balance.
Indications
- Prophylaxis of hypovolemia and shock
- Surgery (hemorrhagic shock)
- Injuries (traumatic shock)
- Burns
- Therapeutic dilution of blood
Therapeutic class
Plasma expander
Pharmacological class
Colloidal Volume Expander (Hydroxyethyl Starch)
Pharmacology
The colloidal solution containing hydroxyethyl starch restores plasma volume by increasing intravascular oncotic pressure. It reduces blood viscosity and improves microcirculation. Sodium chloride maintains electrolyte balance.
Mechanism of action
Restores plasma volume by increasing intravascular oncotic pressure.
Dosage
Adult Dose (IV):
- Up to 50 mL/kg body weight per day (equivalent to 3 g hydroxyethyl starch and 7.7 mEq sodium/kg)
- Up to 3500 mL for a 70 kg patient
Pediatric Dose (IV):
- Newborns & <2 years: Mean dose 16 mL/kg
- 2-12 years: Mean dose 36 mL/kg
- Give initial 10-20 mL by slow IV infusion and monitor for anaphylactoid reaction
Administration
- Administered by healthcare professional as slow IV infusion
- In severe dehydration, give crystalloid solution first
Missed dose
If you miss a dose, consult your doctor.
Side effects
Side Effects (<10%):
- Immune system disorders (rare): Anaphylactoid reactions (mild influenza-like symptoms, bradycardia, tachycardia, bronchospasm, non-cardiac pulmonary edema)
- Skin and subcutaneous tissue disorders (common, dose-dependent): Prolonged administration of high doses may cause pruritus (itching)
Precautions & warnings
- Anaphylactoid reactions may occur; if hypersensitivity occurs, discontinue immediately
- Regularly assess fluid status and infusion rate (especially in cardiac insufficiency or severe kidney dysfunction)
- Caution in severe liver disease or severe bleeding disorders
- Contraindicated in renal failure with oliguria or anuria
Contraindications
- Hypersensitivity to hydroxyethyl starch
- Fluid overload (hyperhydration) especially pulmonary edema and congestive heart failure
- Renal failure with oliguria or anuria (not related to hypovolemia)
- Patients receiving dialysis treatment
- Severe hypernatremia or severe hyperchloremia
- Intracranial bleeding
Drug interactions
No known drug interactions.
Food interactions
Not food-related.
Use in pregnancy
Use in Pregnancy: Safety unknown; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safety unknown; consult your doctor.
Pediatric use
Pediatric dose based on weight and condition; consult your doctor.
Geriatric use
Monitor cardiac and renal function in elderly patients.
Renal / hepatic impairment
Renal Impairment: Caution in severe kidney dysfunction; contraindicated in oliguria/anuria; consult your doctor.
Hepatic Impairment: Caution in severe liver disease; consult your doctor.
Overdose effects
Overdose may cause fluid overload, pulmonary edema, heart failure; treatment: stop infusion, diuretics, symptomatic supportive care.
Storage conditions
Store in a cool and dry place; keep out of reach of children.
Chemical structure
Poly (0-2-hydroxyethyl) starch 60g + Sodium Chloride