Pregabalin

Pregabalin is a medicine used to relieve pain caused by nerve damage (neuropathic pain) due to diabetes, shingles (herpes zoster infection), spinal cord injury, or other conditions. It is also used to treat widespread muscle pain and stiffness in people with fibromyalgia. Pregabalin belongs to the anti-epileptic group of medicines and can be used to treat certain types of seizures (fits) in combination with other medicines. It may also be prescribed to treat the symptoms of excessive anxiety in generalized anxiety disorder if other medicines are not suitable. You can take Pregabalin with or without food, but it is important to take this medicine at the same time each day to get the most benefit. The exact dose and duration of treatment will depend on your condition and how you respond to it. Your doctor will probably start this medicine at a low dose and increase it gradually. It may take a few weeks for the medicine to work properly. Follow your doctor's instructions and continue taking it regularly until your doctor advises you to stop. Do not miss any dose, otherwise, your condition may worsen. The side effects of this medicine are usually mild and go away by themselves. The most common ones are feeling sleepy or dizzy, dryness in the mouth, blurred vision, weight gain, edema (swelling over the whole body), and difficulty in concentrating. Most side effects are not serious and do not need medical attention. Talk to your doctor about potential side effects and ways in which you might prevent or cope with them. Before taking the medicine you should tell your doctor if you are pregnant, breastfeeding or planning to become pregnant. Be careful while driving as sleepiness, dizziness, and blurring of vision may be seen as side effects. You should avoid drinking alcohol along with this medicine as it may lead to excessive sleepiness and dizziness. Pregabalin is an antiepileptic medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures. It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain. For treatment of anxiety, it is believed to work by stopping the release of certain chemical messengers (neurotransmitters) that make you feel anxious.

• Neuropathic pain • Epilepsy/Seizures • Fibromyalgia

Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, calcitonin gene-related peptide and substance P.

Adult Dose: Oral Neuropathic pain, Postherpetic Neuralgia Adult: Initially, 150 mg/day, may increase to 300 mg/day after 3-7 days. Max: 600 mg/day after a 7-day interval. All doses to be given in 2 or 3 divided doses. Diabetic Peripheral Neuropathic Pain Initial: 50 mg PO q8hr Maintenance: May increase to 100 mg PO q8hr within 1 week, as needed; not to exceed 300 mg/day Adjunct in partial seizures Adult: Initially, 150 mg/day, may increase to 300 mg/day after a wk. Max: 600 mg/day. All doses to be given in 2 or 3 divided doses. Fibromyalgia Adult: Initially, 150 mg/day, may increase to 300 mg/day after a wk. Max: 450 mg/day, if needed. All doses to be given in 2 or 3 divided doses. Child Dose: Safety and efficacy not established Renal Dose: Renal impairment: Haemodialysis: 25-100 mg immediately after each 4-hr haemodialysis session. CrCl (ml/min) Dosage Recommendation 30 to <60 75 mg/day. Max: 300 mg/day. All doses to be given in 2 or 3 divided doses. 15 to <30 Initially, 25-50 mg/day. Max: 150 mg/day. All doses to be given as a single dose or in 2 divided doses. <15 Initially, 25 mg/day. Max: 75 mg/day. All doses to be given as a single dose.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Pregabalin may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Pregabalin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Blurred vision • Difficulty in paying attention • Dizziness • Dryness in mouth • Edema (swelling) • Sleepiness • Weight gain

[UNSAFE] Pregabalin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Pregabalin should be taken as per the dose and duration prescribed by your doctor. It may cause sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause blurring or loss of vision. Inform your doctor immediately if you notice any vision changes. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not stop taking the medication suddenly without talking to your doctor as it may worsen your underlying condition.

Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.

May potentiate the effects of lorazepam. Additive CNS depressant effects w/ opiates and benzodiazepines. May increase risk of angioedema w/ ACE inhibitors. May increase risk of wt gain and peripheral oedema w/ thiazolidinediones.

[UNSAFE] Pregabalin may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Pregabalin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Pregabalin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Pregabalin should be used with caution in patients with kidney disease. Dose adjustment of Pregabalin may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Pregabalin is safe to use in patients with liver disease. No dose adjustment of Pregabalin is recommended.

Spondilities and severe neck pain TAB. LYRICA 75MG AT BEDTIME. AVOID USING PILLOW. Can i take lyrica 75 mg substitute as suggested on 1mg for spine pain recommended by doctor ? Which substitute is best? Lyrics is good else you can take any substitute containing Pregabalin" eg Meganeuron-PG" Having nerologiacal pain in right side of head and behind ear .taking lyrica. 150 and zenoxa 300 teptomer 25 but again and again its coming up Can be due to cervical as well. Do light massage with warm majanarayan oil and hot steam towel. 1tsp of triphla powder at night with warm water.Potli massage is the best. To know more about pls visit Www.facebook.com/ayulife Fibromyalgia medicine?. Is there any medicine? you can take Ashwagandha tabet /capsule1-1 Capsule after lunch & dinner. She has problem of epilepsy from last two years Hello, epilepsy and seizures cannot be treated online without physically examining the child and detailed history. Post L5 S1 surgery my right leg numbness still persist. As per advise taking lyrica 75 mg n evion LC daily. But no use pls advise try tab pramipex 0.25 mg HS