Generic
Salicylic Acid + Clobetasol Propionate
1 brands available in the market
At a glance
Salicylic Acid + Clobetasol Propionate is a topical ointment used for psoriasis, chronic atopic dermatitis, neurodermatitis, lichen planus, eczema, and seborrheic dermatitis. It combines a high-potency corticosteroid with a keratolytic agent.
Description
Salicylic Acid + Clobetasol Propionate is a combination ointment. Clobetasol Propionate is a high-potency corticosteroid that decreases inflammation by stabilizing leukocyte lysosomal membranes, inhibiting macrophage accumulation, and reducing capillary permeability. Salicylic Acid acts as a keratolytic agent, softening and destroying the stratum corneum and removing dead skin.
Indications
- Psoriasis
- Chronic atopic dermatitis
- Neurodermatitis (lichen simplex chronicus)
- Lichen planus
- Eczema (nummular eczema, hand eczema)
- Seborrheic dermatitis of the scalp
- Ichthyosis vulgaris
Therapeutic class
Topical Corticosteroid + Keratolytic
Pharmacological class
Clobetasol Propionate + Salicylic Acid
Pharmacology
Clobetasol Propionate stabilizes leukocyte lysosomal membranes, inhibits inflammatory cell accumulation, reduces capillary permeability and edema, and decreases fibroblast proliferation. Salicylic Acid increases endogenous hydration to soften and destroy the stratum corneum and remove dead skin.
Mechanism of action
Reduces inflammation and removes dead skin to treat dermatological conditions.
Dosage
Adult:
- Apply a thin layer to affected areas twice daily with gentle massage
- Reduce frequency once control is achieved
- Do not use for more than 2 consecutive weeks (max 50 gm/week)
- Do not use with occlusive dressings
Administration
- Apply a thin layer to affected skin and massage gently
- Avoid contact with eyes
- Use as directed by a physician
Missed dose
If you miss an application, apply at the next scheduled time.
Side effects
Side Effects:
- Hypercortisolism with prolonged or extensive use
- Local atrophy
- Skin dryness and irritation
- Allergic reactions
Precautions & warnings
- Caution when using near the eyes
- Prolonged use on large areas may cause adrenal suppression
- Infected lesions require antimicrobial therapy
- Caution in psoriasis (rebound relapses, generalized pustular psoriasis)
- Not recommended for children under 12 years; contraindicated under 1 year
Contraindications
- Hypersensitivity to clobetasol propionate or salicylic acid
- Primary bacterial or fungal skin infections (without anti-infective)
- Primary viral skin infections (herpes simplex, vaccinia, varicella)
- Tuberculous skin lesions
- Dermatoses in children under 1 year
Drug interactions
- Avoid concomitant use with other topical medicines (salicylic acid may increase absorption)
Food interactions
Alcohol consumption is not relevant (topical application).
Use in pregnancy
Use in Pregnancy: Safety not established; do not use extensively or for prolonged periods; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Safety not established; use with caution; consult your doctor.
Pediatric use
Not recommended for children under 12 years; contraindicated under 1 year
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Caution needed in kidney disease; consult your doctor.
Hepatic Impairment: Caution needed in liver disease; consult your doctor.
Overdose effects
Acute overdose unlikely; chronic overdose may cause hypercortisolism; discontinue gradually; salicylate toxicity symptoms (tinnitus, dizziness) may occur.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.
Chemical structure
Salicylic Acid + Clobetasol Propionate