Generic
Spiramycine
3 brands available in the market
At a glance
Spiramycine is a macrolide antibiotic used for the treatment of toxoplasmosis in pregnant women. It helps lower the risk of transmission of toxoplasma infection from the mother to the unborn child.
Description
Spiramycine is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S ribosomal subunit, blocking transpeptidation or translocation reactions. It is effective against Toxoplasma gondii and is used for toxoplasmosis during pregnancy.
Indications
- Toxoplasmosis during pregnancy
- Protozoal infections
- Cryptosporidiosis
Therapeutic class
Macrolide Antibiotic
Pharmacological class
Macrolide
Pharmacology
Spiramycine binds to the 50S ribosomal subunit, blocking transpeptidation or translocation reactions, resulting in stunted bacterial cell growth and protein synthesis inhibition.
Mechanism of action
Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
Dosage
Adult Dose (Oral):
- Toxoplasmosis/Protozoal infections: 6-9 million units/day in 2-3 divided doses
- Severe infections: Up to 15 million units/day
Pediatric/Neonatal Dose (Oral):
- Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg twice daily
Administration
- Take on an empty stomach
- Swallow tablet whole; do not chew, crush, or break
- Complete the full course as prescribed by your doctor
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for the next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Nausea, vomiting
- Abdominal pain
- Diarrhea
- Allergy
Precautions & warnings
- Regular monitoring of liver function tests (LFT) may be required
- Safe during pregnancy; however, will not affect severity if unborn child is already infected
- Inform doctor if you have any history of allergy
Contraindications
- Hypersensitivity to spiramycine
Drug interactions
- Carbidopa: Decreased absorption; Levodopa: Decreased concentrations
- Astemizole, cisapride, terfenadine: Increased risk of ventricular arrhythmias
- Fluphenazine: Risk of acute dystonia
Food interactions
Alcohol is safe with Spiramycine.
Use in pregnancy
Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Information not available; consult your doctor.
Pediatric use
Indicated for children and neonates
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Safe in kidney disease; no dose adjustment needed; consult your doctor.
Hepatic Impairment: Limited information; consult your doctor.
Overdose effects
No overdose information available; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.
Chemical structure
Spiramycine