Generic
Sucroferric Oxyhydroxide
1 brands available in the market
At a glance
Sucroferric Oxyhydroxide is a phosphate binder used for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.
Description
Sucroferric Oxyhydroxide is a phosphate binder that binds to dietary phosphate through ligand exchange in the gastrointestinal tract. The bound phosphate is eliminated with feces, reducing phosphate absorption and lowering serum phosphorus and calcium-phosphorus product levels.
Indications
- Hyperphosphatemia in chronic kidney disease patients on dialysis
Therapeutic class
Phosphate Binder
Pharmacological class
Iron-based Phosphate Binder
Pharmacology
Sucroferric Oxyhydroxide binds to phosphate in the aqueous environment of the GI tract through ligand exchange between hydroxyl groups and/or water and dietary phosphate. The bound phosphate is eliminated with feces, reducing dietary phosphate absorption and lowering serum phosphorus and calcium-phosphorus product levels.
Mechanism of action
Binds to dietary phosphate to inhibit phosphate absorption.
Dosage
Adult Dose (Oral):
- Starting: 3 tablets (1500 mg) per day (1 tablet with each meal)
- Dose titration: Adjust by 500 mg (1 tablet) per day based on serum phosphorus levels
- Maximum: 6 tablets (3000 mg) per day
Administration
- Tablets must be chewed or crushed; do not swallow whole
- Take with meals (distribute among meals)
- Take at the scheduled time
Missed dose
If a dose is missed, resume with the next meal; do not attempt to replace the missed dose.
Side effects
Common Side Effects:
- Discolored feces (12%)
- Diarrhea (6%)
Precautions & warnings
- Monitor patients with peritonitis, significant gastric/hepatic disorders, major GI surgery history, hemochromatosis, or iron accumulation diseases
- Caution in pregnancy and lactation
Contraindications
- Hypersensitivity to any component
Drug interactions
- Calcitriol, ciprofloxacin, digoxin, enalapril, furosemide, statins, hydrochlorothiazide, losartan, metoprolol, nifedipine, omeprazole, quinidine, warfarin: Can be coadministered
- Acetylsalicylic acid, cephalexin, doxycycline: Take at least 1 hour before
- Levothyroxine: Take at least 4 hours before
Food interactions
Caution is advised when consuming alcohol with Sucroferric Oxyhydroxide; consult your doctor.
Use in pregnancy
Use in Pregnancy: No adequate controlled studies; animal studies showed post-implantation loss; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Iron absorption is minimal; excretion in breast milk is unlikely; caution required; consult your doctor.
Pediatric use
Safety and efficacy not established in pediatric patients
Geriatric use
Safe for elderly (no dose adjustment needed)
Renal / hepatic impairment
Renal Impairment: Indicated for dialysis patients; consult your doctor.
Hepatic Impairment: Caution required; consult your doctor.
Overdose effects
No overdose data available; excessive doses may cause iron accumulation; consult your doctor.
Storage conditions
Store below 25°C; keep away from light and moisture; keep out of reach of children.
Chemical structure
Sucroferric Oxyhydroxide