Generic
Sulfinpyrazone
1 brands available in the market
At a glance
Sulfinpyrazone is a uricosuric drug used for the treatment of hyperuricemia with gout. It increases uric acid excretion by inhibiting tubular reabsorption of uric acid in the renal tubules.
Description
Sulfinpyrazone is a uricosuric agent that inhibits tubular reabsorption of uric acid in the proximal renal tubules, increasing urinary excretion of uric acid. It also decreases platelet aggregation.
Indications
- Hyperuricemia with gout
Therapeutic class
Drugs Used in Gout
Pharmacological class
Uricosuric Agent
Pharmacology
Sulfinpyrazone inhibits tubular reabsorption of uric acid in the renal proximal tubules, increasing urinary uric acid excretion. It also decreases platelet aggregation.
Mechanism of action
Increases urinary uric acid excretion by inhibiting tubular reabsorption.
Dosage
Adult Dose (Oral):
- Start: 100-200 mg twice daily; gradually increase over 2-3 weeks to 600 mg daily
- Maintenance: After plasma urate controlled, 200 mg daily in divided doses
- Maximum: 800 mg daily
Administration
- Take with food
- Drink plenty of water (approximately 2-3 L/day)
- Ensure urine alkalinization
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for the next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Nausea, vomiting, diarrhea
- Skin rashes
- Renal impairment or failure
- Salt and water retention
- Blood dyscrasia, jaundice, hepatitis
- Acute gout attacks
- Uric acid renal calculi (with inadequate fluid intake)
Precautions & warnings
- Caution in patients with heart failure
- Reduce dose in mild-moderate renal impairment
- Caution in pregnancy and lactation
- Ensure adequate fluid intake (2-3 L/day) and urine alkalinization
- Monitor renal function and blood counts
Contraindications
- Hypersensitivity to sulfinpyrazone and other pyrazolone derivatives
- Aspirin or other NSAID-induced asthma, urticaria, or acute rhinitis
- Acute gout attack
- Blood coagulation disorders
- Uric acid renal calculi
- Porphyria, peptic ulceration
- Severe hepatic and renal impairment
Drug interactions
- Diuretics, pyrazinamide: Increase uric acid concentration (decreased therapeutic effect)
- Coumarin anticoagulants, hypoglycemic agents, sulfonamides: Potentiate action
- Theophylline: Decrease plasma levels
- Penicillins, phenytoin: Increase plasma levels
- NSAIDs: Increased bleeding risk
- Probenecid: Inhibits renal tubular secretion
- Salicylates: Antagonize effect (potentially fatal)
Food interactions
Caution is advised when consuming alcohol with Sulfinpyrazone; consult your doctor.
Use in pregnancy
Use in Pregnancy: Adequate information not available; use if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Adequate information not available; caution required; consult your doctor.
Pediatric use
Safety and efficacy not established in children
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Mild-moderate: reduce dose; severe: contraindicated; consult your doctor.
Hepatic Impairment: Severe: avoid; consult your doctor.
Overdose effects
Overdose may cause nausea, diarrhea, renal problems; provide symptomatic treatment.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.
Chemical structure
Sulfinpyrazone