Generic
Trifluridine 1% Eye prep
1 brands available in the market
At a glance
Trifluridine 1% Eye prep is indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, type 1 and 2.
Description
Trifluridine is a fluorinated pyrimidine nucleoside analog which interferes with DNA synthesis of herpes simplex virus, type 1 and 2 and vaccinia virus. It stops replication of herpes viral DNA by competitive inhibition of viral DNA polymerase, incorporation into and termination of the growing viral DNA chain, and inactivation of the viral DNA polymerase.
Indications
- Primary keratoconjunctivitis due to herpes simplex virus
- Recurrent epithelial keratitis due to herpes simplex virus
Therapeutic class
Ophthalmic Anti-viral Products
Pharmacological class
Antiviral
Pharmacology
Trifluridine is a fluorinated pyrimidine nucleoside analog which interferes with DNA synthesis of herpes simplex virus, type 1 and 2 and vaccinia virus. It stops replication of herpes viral DNA in 3 ways: competitive inhibition of viral DNA polymerase, incorporation into and termination of the growing viral DNA chain, and inactivation of the viral DNA polymerase.
Mechanism of action
Interferes with viral DNA synthesis, stopping herpes virus replication.
Dosage
Adult and Child (>6 years) Dose (Ophthalmic):
- Instill 1 drop into affected eye every 2 hours; max 9 drops daily until complete re-epithelialisation
- After re-epithelialisation: 1 drop every 4 hours (min 5 drops daily) for 7 days
- Treatment should not exceed 21 days
Administration
- For ophthalmic use only
- Use under close supervision of an ophthalmologist
- Consider other therapy if no improvement after 7 days or no complete re-epithelialisation after 14 days
Missed dose
If you miss a dose, apply it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Transient burning or stinging upon instillation
- Irritation
- Hyperemia
- Palpebral oedema
- Dry eye
- Superficial punctate keratopathy
- Epithelial keratopathy
- Hypersensitivity reaction
- Increased intraocular pressure
Precautions & warnings
- Caution in pregnancy
- Not recommended for children under 6 years
- Use under close supervision of an ophthalmologist
- Avoid continuous administration for more than 21 days (risk of ocular toxicity)
Contraindications
- Hypersensitivity
Drug interactions
No known significant interactions.
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Category C; no adequate studies; use only if potential benefit justifies potential risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Unlikely to be excreted in human milk (low dosage); use if potential benefits outweigh potential risks.
Pediatric use
Safety and effectiveness not established in children below 6 years
Geriatric use
No overall clinical differences in safety or effectiveness between elderly and other adult patients
Renal / hepatic impairment
Renal Impairment: Not applicable (ophthalmic application)
Hepatic Impairment: Not applicable (ophthalmic application)
Overdose effects
Overdose is not applicable (ophthalmic application).
Storage conditions
Store between 2-8°C. Do not use longer than 30 days after first opening. Keep out of reach of children.