Generic
Triptorelin Acetate
1 brands available in the market
At a glance
Triptorelin Acetate is used in the treatment of prostate cancer. It is also used to treat endometriosis and central precocious puberty.
Description
Triptorelin is a synthetic analogue of natural gonadotropin-releasing hormone. Initial administration stimulates the release of pituitary gonadotrophins with a transient increase in testosterone levels in men and oestradiol levels in women. Prolonged administration leads to suppression of gonadotrophins and a decrease in plasma testosterone or oestradiol.
Indications
- Prostate cancer
- Endometriosis
- Precocious puberty
- Uterine fibroids
- Female infertility
Therapeutic class
LHRH Analogue
Pharmacological class
Gonadotropin-Releasing Hormone (GnRH) Analogue
Pharmacology
Triptorelin is a synthetic analogue of natural gonadotropin-releasing hormone. Initial administration stimulates the release of pituitary gonadotrophins with a transient increase in testosterone levels in men and oestradiol levels in women, leading to an initial worsening of symptoms during the first week. Prolonged administration leads to suppression of gonadotrophins and a decrease in plasma testosterone or oestradiol after approximately 20 days.
Mechanism of action
Modulates gonadotrophin release, decreasing testosterone/oestradiol levels.
Dosage
Adult Dose (Parenteral):
- Prostate cancer: 22.5 mg IM every 6 months, or 11.25 mg IM every 3 months, or 3.75 mg IM every month
- Endometriosis/Uterine fibroids: 3 or 3.75 mg IM every 4 weeks for up to 6 months; begin during the first 5 days of the menstrual cycle
- Female infertility: 0.1 mg daily SC, in conjunction with gonadotrophins, starting from the 2nd day of the menstrual cycle for 10-12 days
Child Dose: 30 kg: 3.75 mg IM or SC; first 3 doses at 14-day intervals, then every 4 weeks
Administration
- Administered by a doctor or nurse; do not self-administer
- Administered as IM or SC injection
Missed dose
If you miss a dose, consult your doctor.
Side effects
Common Side Effects:
- Weakness
- Increased sweating
- Back pain
- Paresthesia
- Decreased libido
- Impotence
- Hot flashes
- Fatigue
Precautions & warnings
- May affect ability to drive
- May cause dizziness, tiredness or blurred vision
- Menstrual periods will stop; resume 7-12 weeks after final injection
- Consult doctor if menstrual bleeding continues during treatment
- Use non-hormonal contraception to prevent pregnancy
- Long-term treatment may lead to bone loss and higher risk of fractures
- Take vitamin D and calcium supplements
Contraindications
- Hypersensitivity to triptorelin and other LHRH agonists
- As sole treatment in prostate cancer patients with spinal cord compression or evidence of spinal metastases
- Progressive brain tumours in children
- Pregnancy
- Lactation
Drug interactions
- Hyperprolactinaemic drugs: decrease in LHRH receptors in pituitary antagonises effects of triptorelin
Food interactions
It is not known whether it is safe to consume alcohol with Triptorelin Acetate; consult your doctor.
Use in pregnancy
Use in Pregnancy: Highly unsafe; studies show significant harmful effects to the developing baby; consult your doctor.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Information not available; consult your doctor.
Pediatric use
Used in children for precocious puberty; contraindicated in progressive brain tumours
Geriatric use
Caution required in elderly patients
Renal / hepatic impairment
Renal Impairment: Caution needed; dose adjustment may be needed
Hepatic Impairment: Caution needed; dose adjustment may be needed
Overdose effects
Symptoms: Hot flashes, dizziness, electrolyte imbalance.
Treatment: Supportive care.
Storage conditions
Store at 15-30°C, away from light; keep out of reach of children.