Generic
Undenatured Type II Collagen + Hyaluronic Acid + Boswellia Serrata + Vitamin C
2 brands available in the market
At a glance
Undenatured Type II Collagen + Hyaluronic Acid + Boswellia Serrata + Vitamin C is indicated for osteoporosis, osteoarthritis, osteomalacia, osteopenia, pain & inflammation associated with musculoskeletal and joint disease, joint immobility and rigidity, rheumatoid arthritis, and strenuous exercise and sports injury.
Description
Undenatured Collagen II is derived from chicken sternum cartilage preserving the triple helix. Boswellic acid inhibits 5-LOX. Hyaluronic acid binds water, providing lubrication and shock absorption. Vitamin C is an antioxidant and aids collagen formation.
Indications
- Osteoporosis
- Osteoarthritis
- Osteomalacia
- Osteopenia
- Pain & inflammation associated with musculoskeletal and joint disease
- Joint immobility and rigidity
- Rheumatoid arthritis
- Strenuous exercise and sports injury
Therapeutic class
Drugs for Osteoarthritis, Herbal and Nutraceuticals
Pharmacological class
Herbal and Nutraceuticals
Pharmacology
Undenatured Collagen II is derived from chicken sternum cartilage preserving the triple helix. Boswellic acid from Boswellia serrata inhibits 5-LOX. Hyaluronic acid binds water, providing lubrication and shock absorption. Vitamin C is an antioxidant and aids collagen formation.
Mechanism of action
Collagen II acts as an antigen, stimulating anti-inflammatory cytokine production. Undenatured collagen II epitopes trigger oral tolerization, releasing collagen-specific regulatory T-cells. Boswellic acid inhibits 5-LOX. Hyaluronic acid binds CD-44 receptor. Vitamin C increases proline hydroxylation and procollagen synthesis.
Dosage
Adult Dose (Oral):
- 1 capsule daily after a meal with water or as directed by the physician
Administration
- Take after a meal
- Take as directed by a physician
Missed dose
If you miss a dose, take it as soon as you remember; if almost time for next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Generally well tolerated
- Occasionally mild epigastric pain, constipation, diarrhea, bloating, and nausea
- Rarely headache and visual disturbance
Precautions & warnings
- Caution with anticoagulants
- Hyaluronic acid can alter GI absorption of certain antibiotics
- Can be used with analgesics or anti-inflammatory drugs
Contraindications
- Hypersensitivity to Undenatured Collagen II, Hyaluronic Acid, Boswellia Serrata, and Vitamin C
- Not recommended for patients under 12 years and for patients with phenylketonuria or severe renal insufficiency
Drug interactions
- Anticoagulants: caution required
- Hyaluronic acid can alter GI absorption of certain antibiotics
- Boswellia serrata may lower blood glucose; dose adjustment of antidiabetic drugs may be needed
Food interactions
Food interactions are not significant.
Use in pregnancy
Use in Pregnancy: Limited scientific information.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Limited scientific information.
Pediatric use
Not recommended for patients under 12 years
Geriatric use
Safe for elderly
Renal / hepatic impairment
Renal Impairment: Not recommended for severe renal insufficiency
Hepatic Impairment: Limited information
Overdose effects
Symptoms: Headache, visual disturbance.
Treatment: Supportive care.
Storage conditions
Do not store above 30°C. Protect from light and moisture. Keep out of reach of children.