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At a glance

Carbonic anhydrase inhibitor used in open-angle glaucoma, secondary glaucoma, edema, and as an adjuvant in epilepsy.

Indications

Indicated in open angle glaucoma, secondary glaucoma, and as an adjuvant in the treatment of edema and epilepsy.

Pharmacology

Acetazolamide inhibits carbonic anhydrase enzyme, decreasing the secretion of aqueous humor in the eye and dropping intraocular pressure. In the CNS, it retards abnormal paroxysmal neuronal discharges.

Dosage

Adults: Initially 250 mg (1 tablet) 4 times daily. Acute intraocular pressure: 2 tablets (500 mg) initially followed by 1 tablet every 6 hours. Children: 0.5 to 2 tablets in divided doses.

Side effects

Common: Headache, drowsiness, dizziness, fatigue, anorexia, polyuria, insomnia, gastrointestinal upset, and paresthesia.

Use in pregnancy

Pregnancy Category C. Use only if clearly needed and benefits outweigh potential risks to fetus.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings

Monitor serum electrolytes for hypokalemia or hyponatremia and observe for metabolic acidosis during long-term therapy.

Overdose effects

Overdose may cause electrolyte imbalance, metabolic acidosis, and CNS effects. Treatment is supportive.

Storage conditions

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Acetazolamide — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.