৳ 35/unit
Pack: ৳ 700
৳ 35/unit
Pack: ৳ 700
At a glance
Atypical antidepressant acting as a melatonergic agonist and 5-HT2C antagonist for major depressive disorder.
Indications
Major depressive disorder in adults, particularly in non-responders or those intolerant to SSRIs, including the prevention of relapse.
Pharmacology
Agomelatine acts on MT1 and MT2 receptors and antagonizes 5-HT2C receptors, leading to increased noradrenaline and dopamine release in the frontal cortex while having no effect on extracellular serotonin levels.
Dosage
25 mg once daily at bedtime. If no clinical improvement is observed after 2 weeks, the dose may be increased to 50 mg once daily at bedtime.
Side effects
Common: Headache, nausea, diarrhea, fatigue, and dizziness. Potentially increases liver enzymes (transaminases). Low incidence of sexual dysfunction.
Use in pregnancy
No adequate clinical data on pregnant women. Prescribe with caution only if potential benefit outweighs risk.
Pregnancy Category: Antidepressant Precaution — always consult a doctor before taking during pregnancy.
Precautions & warnings
Perform baseline liver function tests (LFTs) and monitor periodically (e.g., at 6 weeks). Use with caution in patients with a history of mania or bipolar disorder.
Overdose effects
Overdosage leads to drowsiness and epigastric pain. Manage with symptomatic treatment and clinical monitoring.
Storage conditions
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.