৳ 1,631.25/unit
Pack: ৳ 1,631.25
৳ 1,631.25/unit
Pack: ৳ 1,631.25
At a glance
Flumazenil is an antidote used to reverse the sedative effects of benzodiazepines given during surgery.
Indications
- Benzodiazepine Overdose: Used for reversal of centrally sedative effects of benzodiazepines in anaesthesia and intensive care.
- Diagnosis of Unconsciousness: Used to differentiate between benzodiazepine involvement and other causes in unconsciousness of unknown origin.
Pharmacology
Flumazenil is an antitode, which is used to reverse the effect of medicine benzodiazepine given during surgery for sedation. It blocks the action of benzodiazepines by acting on GABA receptors, thereby reversing the sedation effect.
Dosage
Adult Dose (IV):
- Anaesthesia: Initial: 0.2 mg IV over 15 seconds; if desired consciousness not obtained within 60 seconds, repeat 0.1 mg (at 60-second intervals, max 1 mg); usual dose: 0.3-0.6 mg.
- Intensive Care/Unconsciousness: Initial: 0.3 mg IV; if desired consciousness not obtained within 60 seconds, repeat (max 2 mg); for re-sedation: 0.1-0.4 mg/hr IV infusion.
Child Dose (>1 year): Initial: 0.01 mg/kg (max 0.2 mg) IV over 15 seconds; repeat if needed after 45 seconds (max 0.05 mg/kg or 1 mg, whichever is lower).
Side effects
Common Side Effects: Anxiety, Insomnia, Allergic reaction, Sleepiness, Palpitations, Fear.
Serious Side Effects: Seizures (in epileptic patients or severe hepatic impairment), withdrawal symptoms (in long-term benzodiazepine users).
Use in pregnancy
Use in Pregnancy: Flumazenil may be unsafe; animal studies have shown harmful effects; parenteral administration in emergencies is not contraindicated.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions: It is not known whether Flumazenil alters the ability to drive; do not drive if you experience any symptoms. Particular caution in mixed-substance overdose. Not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period. Caution in patients with head injury. Avoid rapid injection. Not recommended for treatment of benzodiazepine dependence or protracted abstinence syndromes.
Overdose effects
Overdose: Limited information on overdose; well tolerated even at doses exceeding recommended; symptomatic treatment.
Storage conditions
Storage: Keep below 30 degree C, away from light and moisture. Keep out of reach of children.