৳ 9/unit
Pack: ৳ 90
৳ 9/unit
Pack: ৳ 90
At a glance
Domperidone is a prokinetic medication used for the treatment of nausea, vomiting, and indigestion.
Indications
- Dyspeptic symptom complex (fullness, bloating, heartburn)
- Nausea and vomiting
- Non-ulcer dyspepsia
- Dopamine-agonist-induced nausea and vomiting in Parkinson's disease
Pharmacology
Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of the gastrointestinal tract.
Dosage
Adult (Nausea/Vomiting): 10-20 mg every 4-8 hours (max 80 mg/day).
Adult (Dyspepsia): 10 mg 3-4 times daily (max 20 mg 3-4 times daily, last dose at bedtime).
Child: 0.2-0.4 mg/kg every 4-8 hours.
Side effects
Common: Headache, dry mouth, stomach pain, diarrhea.
Rare: Transient intestinal cramps, extrapyramidal reactions (in children), hyperprolactinemia (galactorrhea, gynecomastia), allergic reactions.
Use in pregnancy
Pregnancy Category C. Use during pregnancy only if clearly needed and under medical advice.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
May affect driving ability (drowsiness, dizziness). Avoid alcohol. Do not use in GI hemorrhage, obstruction, or perforation. Do not use for longer than 7 days without consulting your doctor. Caution in liver and kidney disease.
Overdose effects
Overdose may cause drowsiness, disorientation, extrapyramidal reactions (especially in children); activated charcoal and observation; anticholinergic drugs may be helpful.
Storage conditions
Keep below 30°C temperature, away from light & moisture.