৳ 8/unit
Pack: ৳ 80
৳ 8/unit
Pack: ৳ 80
At a glance
Amlodipine + Atorvastatin is a combination medicine used for the treatment of hypertension with high cholesterol levels. It helps reduce the risk of stroke and heart attack.
Indications
- Hypertension
- Chronic stable angina
- Coronary Artery Disease (CAD)
- Primary hypercholesterolemia (heterozygous familial and non-familial)
- Mixed dyslipidemia (Fredrickson Types IIa and IIb)
- Hypertriglyceridemia (Fredrickson Type IV)
- Primary dysbetalipoproteinemia (Fredrickson Type III)
- Homozygous Familial Hypercholesterolemia (HoFH)
Pharmacology
Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to reduce peripheral vascular resistance and lower blood pressure. The vasodilation induced by amlodipine is gradual in onset, so acute hypotension is rarely reported after oral administration.
Atorvastatin is a synthetic lipid-lowering agent that inhibits HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol synthesis.
Dosage
Amlodipine:
- Hypertension: 5 mg once daily (maximum 10 mg)
- Elderly/Hepatic impairment: Start with 2.5 mg once daily
- Chronic stable/vasospastic angina: 5-10 mg daily
Atorvastatin:
- Hypercholesterolemia & mixed dyslipidemia: Start with 10 mg daily (range 10-80 mg)
- Homozygous FH: 10-80 mg daily
- Renal impairment: No dose adjustment needed
- Hepatic dysfunction: Exposure is increased in moderate-severe disease
Side effects
- Headache
- Nausea
- Stomach pain
- Flushing
- Ankle swelling
- Palpitations
- Constipation
- Muscle pain
- Tiredness
- Sleepiness
- Increased blood glucose
- Increased liver enzymes
Use in pregnancy
[UNSAFE] Do not use during pregnancy (Category D). Amlodipine has fetal risk and atorvastatin is contraindicated during pregnancy.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- Patients with severe obstructive coronary artery disease may develop increased frequency of angina or MI when starting calcium channel blocker therapy or increasing dose
- Report any muscle pain, tenderness, or weakness to your doctor
- Report signs of liver damage (abdominal pain, dark urine, yellow skin/eyes)
- Do not use during pregnancy and breastfeeding
- Contraindicated in active liver disease or unexplained liver enzyme elevations (>3x ULN)
- Use with caution in patients with heart failure
- Caution in severe aortic stenosis
Overdose effects
No specific antidote for overdose. Symptomatic and supportive treatment is required. Amlodipine overdose may cause excessive peripheral vasodilation and reflex tachycardia.
Storage conditions
Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.