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At a glance

Nelfinavir is an antiretroviral medicine used for HIV infection. It inhibits HIV protease enzyme to prevent production of new viruses.

Indications
  • HIV infection (when antiretroviral therapy is warranted)
Pharmacology

Nelfinavir inhibits HIV-1 protease enzyme to prevent cleavage of viral polyprotein, resulting in noninfectious virus particles.

Dosage

Adult Dose (Oral):

  • 1250 mg (5 x 250 mg tablets) twice daily OR 750 mg (3 x 250 mg tablets) three times daily
  • Take with a meal

Pediatric Dose (2-13 years): 20-30 mg/kg/dose three times daily with a meal

Side effects

Common Side Effects (>2%):

  • Diarrhea (most common)
  • Abdominal pain
  • Nausea, vomiting
  • Dyspepsia
  • Headache
  • Dizziness
  • Rash
  • Throat pain
  • Increased liver enzymes
  • Hypercholesterolemia
  • Increased triglycerides
  • Peripheral neuropathy
Use in pregnancy

Use in Pregnancy: Nelfinavir is safe during pregnancy (Category B); animal studies show low or no adverse effects.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Take with food
  • Complete full course of treatment
  • Monitor liver function regularly
  • Caution while driving (may cause dizziness or drowsiness)
  • Increased bleeding risk in haemophilia patients
Overdose effects

Limited information on overdose; symptomatic treatment.

Storage conditions

Store at 15-30°C.

Nelfinavir — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.