৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Ciprofibrate is a fibrate class medication used as an adjunct to diet, exercise and weight reduction for the treatment of severe hypertriglyceridemia and mixed hyperlipidemia.
Indications
- Severe hypertriglyceridemia (with or without low HDL cholesterol)
- Mixed hyperlipidemia (when a statin is contraindicated or not tolerated)
Pharmacology
Ciprofibrate reduces both LDL and VLDL and hence the levels of triglyceride and cholesterol associated with these lipoprotein fractions. It also increases levels of HDL cholesterol. Ciprofibrate is effective in the treatment of hyperlipidemia associated with high plasma concentrations of LDL and VLDL. There is evidence that treatment with fibrates may reduce coronary heart disease events.
Dosage
Adult Dose: 100 mg once daily (1 tablet per day). This dose should not be exceeded.
Renal Dose: Moderate renal impairment (CrCl 30-80 ml/min/1.73 m²): 1 tablet (100 mg) every other day. Severe renal impairment (CrCl <30 ml/min/1.73 m²): Should not be used.
Hepatic Dose: Use with caution in impaired hepatic function. Discontinue if AST and ALT levels rise to more than 3 times the upper limit of normal or if cholestatic liver injury is evidenced.
Elderly: As for adults but precautions should be taken for age more than 70 years.
Side effects
Common Side Effects:
- Headache
- Dizziness
- Somnolence
- Vertigo
- Nausea
- Vomiting
- Diarrhea
- Dyspepsia
- Abdominal pain
- Rash
- Alopecia
- Myalgia
- Fatigue
Serious Side Effects: Myopathy, rhabdomyolysis, myoglobinuria, elevated liver enzymes.
Use in pregnancy
There is no evidence that Ciprofibrate is teratogenic but signs of toxicity at high doses were observed in animal studies. Contraindicated during pregnancy.
Precautions & warnings
- Myalgia/myopathy: Report unexplained muscle pain, tenderness or weakness immediately.
- Hepatic function tests: Recommended every 3 months for the first 12 months of treatment.
- Patients with rare hereditary problems of galactose intolerance, lactose deficiency or glucose-galactose malabsorption should not take this medicine.
- Contraindicated during pregnancy and lactation.
Overdose effects
Information on Ciprofibrate overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Store below 30°C. Protect from light and moisture. Keep out of reach of children.