৳ 100/unit
Pack: ৳ 600
৳ 100/unit
Pack: ৳ 600
At a glance
Deferasirox is an oral iron chelator used for the treatment of chronic iron overload caused by repeated blood transfusions.
Indications
- Chronic iron overload due to repeated blood transfusions
- Transfusion-dependent thalassemia
- Sickle cell disease and myelodysplastic syndrome
Pharmacology
Deferasirox is an orally active chelator that is highly selective for iron. It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Deferasirox promotes excretion of iron, primarily in the faeces.
Dosage
Adult - Transfusional Hemosiderosis: 20 mg/kg once daily orally; may increase by 5-10 mg based on serum ferritin; maximum 40 mg/kg/day.
Adult - Nontransfusion-Dependent Thalassemia: 10 mg/kg once daily.
Side effects
Common: Nausea, headache, vomiting, rash, abdominal pain, constipation, itching, increased liver enzymes, abdominal distension, diarrhea.
Serious: Cytopenias, gastrointestinal ulceration and hemorrhage, Stevens-Johnson syndrome (SJS), auditory and ocular disturbances.
Use in pregnancy
Pregnancy Category C. Deferasirox may be unsafe during pregnancy. Animal studies have shown harmful effects on the developing baby. Use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Gastrointestinal bleeding, ulceration and irritation may occur; caution with NSAIDs, corticosteroids, oral bisphosphonates and anticoagulants. Monitor blood counts. Discontinue if serious hypersensitivity reactions occur. Caution while driving (drowsiness, dizziness).
Overdose effects
The maximal dose of Deferasirox is 40 mg/kg body weight. There is no information about overdose.
Storage conditions
Store in a dry place below 25°C, protect from light. Keep out of reach of children.