৳ 230.69/unit
Pack: ৳ 230.69
৳ 230.69/unit
Pack: ৳ 230.69
At a glance
Ipratropium Bromide + Salbutamol combination is used for bronchospasm in patients with COPD who continue to have evidence of bronchospasm on a regular aerosol bronchodilator.
Indications
- Bronchospasm in COPD patients (who continue to have evidence of bronchospasm on a regular aerosol bronchodilator)
Pharmacology
This combination inhalation aerosol contains Salbutamol (short-acting beta2-adrenergic bronchodilator) and Ipratropium Bromide (anticholinergic bronchodilator). Ipratropium Bromide prevents increase in intracellular cyclic GMP caused by interaction of acetylcholine with muscarinic receptor on bronchial smooth muscle. Salbutamol stimulates beta2-adrenergic receptors to relax bronchial smooth muscle. This combination maximizes treatment response in COPD patients by reducing bronchospasm through two distinct mechanisms.
Dosage
Adult Dose (Inhalation):
- Metered-dose inhaler: 100 mcg/20 mcg (1 actuation) every 6 hours; not to exceed 6 actuations/day
- Nebulizer solution: Initially, 3 mL every 6 hours; Max: 3 mL every 4 hours; 3-4 ampoules daily
- One ampoule as required or as directed
Child Dose: Safety and efficacy not established
Side effects
Common Side Effects:
- Dryness in mouth
- Breathlessness
- Cough
- Tremor
- Headache
- Palpitations
- Muscle cramp
Uncommon: Angioedema, Urticaria, Bronchospasm, Hypotension, Nausea, Sinusitis, Pharyngitis, Influenza
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- For inhalation only; do not swallow tablets
- Do not use to relieve sudden breathing problems (use rescue inhaler)
- Take first dose under medical supervision (may cause bronchospasm)
- Gargle with warm water after each inhalation (to avoid fungal infections)
- Caution in narrow-angle glaucoma, prostatic hypertrophy or bladder-neck obstruction
- Hypokalemia may occur; monitor potassium levels
Overdose effects
Overdose: Effects are expected to be related primarily to Salbutamol; manifestations include anginal pain, hypertension, hypokalemia, tachycardia; symptomatic treatment.
Storage conditions
Avoid storage in direct sunlight or heat; store in a cool and dry place; keep away from children; keep away from eyes.