৳ 22/unit
Pack: ৳ 660
৳ 22/unit
Pack: ৳ 660
At a glance
Perindopril + Amlodipine is a combination medicine used to treat hypertension (high blood pressure) when a single medication is not effective. It relaxes blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently.
Indications
- Hypertension (high blood pressure)
Pharmacology
Perindopril inhibits ACE, reducing angiotensin II production, resulting in decreased vasoconstriction and aldosterone secretion. Amlodipine blocks calcium channels, relaxing vascular smooth muscle and reducing peripheral vascular resistance.
Dosage
Adult Dose (Oral):
- Hypertension: 4 mg/5 mg tablet once daily
- Adjust dose according to blood pressure goals; wait 7-14 days between titration steps
- Maximum: 14 mg/10 mg once daily
- Renal impairment (CrCl 30-80 mL/min): Do not exceed 7/5 mg
- CrCl <30 mL/min: Not recommended
Side effects
Common Side Effects:
- Ankle swelling
- Headache
- Fatigue
- Palpitations
- Increased potassium level in blood
- Sleepiness
- Cough
- Taste change
- Flushing
- Decreased blood pressure
- Upset stomach
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby. Discontinue immediately if pregnancy is diagnosed.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if dizziness or weakness occurs
- Do not use during pregnancy and lactation
- Do not use with aliskiren in patients with diabetes or renal impairment
- Monitor renal function, blood pressure, and electrolyte levels
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store in a dry place below 25°C; keep out of reach of children.