৳ 200/unit
Pack: ৳ 200
৳ 200/unit
Pack: ৳ 200
At a glance
Parecoxib is a prodrug that is converted to valdecoxib, a selective COX-2 inhibitor. It is used for the short-term treatment of postoperative pain in adults.
Indications
- Postoperative pain (short-term)
- Post-dental extraction pain
- Post-orthopedic surgery pain
- Post-gynecologic surgery pain
Pharmacology
Parecoxib is a prodrug of valdecoxib. Valdecoxib is a selective COX-2 inhibitor that inhibits prostaglandin synthesis. COX-2 is the isoform of the enzyme induced by pro-inflammatory stimuli and is primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever.
Dosage
Adult Dose (IV/IM):
- Recommended dose: 40 mg IV or IM, followed by 20-40 mg every 6-12 hours as needed; max 80 mg/day
- Limited clinical experience beyond 3 days of treatment
- Elderly (≥65 years): Generally no dose adjustment needed; however, for elderly <50 kg, initiate with half the usual dose and reduce max daily dose to 40 mg
Pediatric Dose: Safety and efficacy not established in children under 18 years; not recommended.
Side effects
Common Side Effects:
- Blood pressure changes (increase or decrease)
- Back pain
- Swelling of ankles, legs, and feet (fluid retention)
- Numbness (loss of sensitivity to pain and touch)
- Vomiting, abdominal pain, indigestion, constipation, bloating, and gas
- Abnormal kidney function tests
- Agitation or difficulty sleeping
- Dizziness
- Anemia (changes in red blood cells post-surgery)
- Sore throat or difficulty breathing
- Itchy skin
- Decreased urine output
- Dry socket (inflammation and pain after tooth extraction)
- Increased sweating
- Low blood potassium levels
Use in pregnancy
Use in Pregnancy: Suspected to cause serious birth defects in the last trimester; may cause premature closure of the ductus arteriosus or uterine inertia. Second and third trimester use may cause fetal renal dysfunction. Contraindicated in the third trimester.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Potential for increased adverse reactions at higher doses compared to other COX-2 inhibitors and NSAIDs; monitor patients after dose increase
- Limited clinical experience beyond 3 days
- Studied in dental, orthopedic, gynecologic, and CABG surgery; limited experience in other surgeries
- Other administration routes (e.g., intra-articular, intrathecal) have not been studied
- If organ system deterioration occurs, consider discontinuation
Overdose effects
Overdose symptoms are similar to adverse reactions seen with recommended doses. Treatment: symptomatic and supportive care. Valdecoxib is not removed by hemodialysis; diuresis or urine alkalinization may not be useful due to high protein binding.
Storage conditions
Store below 30°C in a dry place, protected from light and moisture; keep out of reach of children.