Parix 40

• Postoperative pain (short-term)
• Post-dental extraction pain
• Post-orthopedic surgery pain
• Post-gynecologic surgery pain

Adult Dose (IV/IM):

• Recommended dose: 40 mg IV or IM, followed by 20-40 mg every 6-12 hours as needed; max 80 mg/day
• Limited clinical experience beyond 3 days of treatment
• Elderly (≥65 years): Generally no dose adjustment needed; however, for elderly <50 kg, initiate with half the usual dose and reduce max daily dose to 40 mg

Pediatric Dose: Safety and efficacy not established in children under 18 years; not recommended.

Common Side Effects:

• Blood pressure changes (increase or decrease)
• Back pain
• Swelling of ankles, legs, and feet (fluid retention)
• Numbness (loss of sensitivity to pain and touch)
• Vomiting, abdominal pain, indigestion, constipation, bloating, and gas
• Abnormal kidney function tests
• Agitation or difficulty sleeping
• Dizziness
• Anemia (changes in red blood cells post-surgery)
• Sore throat or difficulty breathing
• Itchy skin
• Decreased urine output
• Dry socket (inflammation and pain after tooth extraction)
• Increased sweating
• Low blood potassium levels

• Potential for increased adverse reactions at higher doses compared to other COX-2 inhibitors and NSAIDs; monitor patients after dose increase
• Limited clinical experience beyond 3 days
• Studied in dental, orthopedic, gynecologic, and CABG surgery; limited experience in other surgeries
• Other administration routes (e.g., intra-articular, intrathecal) have not been studied
• If organ system deterioration occurs, consider discontinuation