৳ 30/unit
Pack: ৳ 300
৳ 30/unit
Pack: ৳ 300
At a glance
Deflazacort is a glucocorticoid with anti-inflammatory and immunosuppressive effects used for the treatment of allergic conditions, asthma, rheumatoid arthritis, leukemia, and immune suppression in transplantation.
Indications
- Anaphylaxis, asthma, severe hypersensitivity reactions
- Rheumatoid arthritis, juvenile chronic arthritis
- Systemic lupus erythematosus, dermatomyositis
- Pemphigus, bullous pemphigoid
- Minimal change nephrotic syndrome
- Ulcerative colitis, Crohn's disease
- Uveitis, optic neuritis
- Autoimmune hemolytic anemia, ITP
- Acute and lymphatic leukemia, malignant lymphoma
- Immune suppression in transplantation
Pharmacology
Deflazacort provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides, Deflazacort decreases the release of certain chemicals that are important in the immune system, providing immunosuppressive action.
Dosage
Adult - Acute disorders: Initially up to 120 mg/day; Maintenance: 3-18 mg/day.
Child: 0.25-1.5 mg/kg/day (on alternate days).
Side effects
Common: Increased appetite, frequent urge to urinate, facial swelling, abnormal hair growth, Cushing syndrome, cough.
Other: GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances, increased infection risk, skin atrophy, acne, thromboembolism.
Use in pregnancy
Pregnancy Category C. Deflazacort crosses the placenta. Prolonged or repeated use during pregnancy may increase the risk of intrauterine growth retardation. Use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Caution in cardiac disease, hypertension, diabetes, osteoporosis, myasthenia gravis, epilepsy, peptic ulcer, liver failure, hypothyroidism, cirrhosis. Avoid live virus vaccines. Inform doctor if signs of infection (fever, sore throat) occur.
Overdose effects
Limited information on overdose. Overdose may increase common corticosteroid side effects. Seek medical attention.
Storage conditions
Store in a cool (below 25°C) and dry place, protected from light & moisture. Keep out of reach of children.