৳ 450/unit
Pack: ৳ 450
৳ 450/unit
Pack: ৳ 450
At a glance
Methylprednisolone Acetate is a potent corticosteroid used for inflammation, allergies, rheumatic disorders, skin and eye diseases, and joint pain.
Indications
- Rheumatic Disorders (Rheumatoid Arthritis, Osteoarthritis, Gout)
- Skin Diseases (Contact Dermatitis, Psoriasis, Pemphigus)
- Allergies (Bronchial Asthma, Allergic Rhinitis)
- Ophthalmic Diseases (Iritis, Keratitis)
- Collagen Diseases (SLE, Dermatomyositis)
- Hematologic Disorders
- Neoplastic Diseases
- Adrenocortical Insufficiency
Pharmacology
Methylprednisolone Acetate binds to and activates intracellular glucocorticoid receptors. Activated receptors bind to promoter regions of DNA, modifying transcription and protein synthesis. It inhibits leukocyte infiltration at the site of inflammation, interferes with mediators of inflammatory response, and suppresses humoral immune responses.
Dosage
Adult Dose:
- Intra-articular: Small joints: 4-10 mg; Medium joints: 10-40 mg; Large joints: 20-80 mg. Repeat every 1-5 weeks.
- Intralesional: 20-60 mg every 1-5 weeks (for dermatoses)
- Intramuscular (Systemic): 10-80 mg every 1-2 weeks
- Adrenogenital Syndrome: 40 mg IM every 2 weeks
- Rheumatoid Arthritis Maintenance: 40-120 mg weekly IM
- Acute Dermatitis (Poison Ivy): 80-120 mg single IM dose
- Asthma/Allergic Rhinitis: 80-120 mg IM
Side effects
Common Side Effects:
- Skin thinning
- Increased risk of infection
- Reduction in bone density
- Weight gain
- Mood changes
- Upset stomach
- Behavioral changes
Injection-related:
- Congestive heart failure
- Hypertension, sodium retention
- Muscle weakness, osteoporosis
- Peptic ulcer, abdominal distention
- Convulsions, headache
- Menstrual irregularities
- Increased intraocular pressure, glaucoma
- Allergic/hypersensitivity reactions
- Urticaria, hyperpigmentation/hypopigmentation
Use in pregnancy
Use in Pregnancy (Category C): Possibly unsafe. Adequate human reproduction studies not done. Weigh benefits against potential risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not stop abruptly (risk of adrenal insufficiency)
- Inform doctor if signs of infection occur
- Do not receive live vaccines
- Monitor blood glucose if diabetic
- Caution in osteoporosis, mood disorders, hypertension, liver disease
- Caution in ocular herpes simplex (corneal perforation)
- Caution with aspirin in hypoprothrombinemia
Overdose effects
Reports of acute toxicity/death are rare. No specific antidote; supportive and symptomatic treatment. Monitor serum electrolytes.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.