Depodrol40mg/ml

Methylprednisolone Acetate is a medicine used to treat wide variety of medical conditions such as severe conditions, asthma, rheumatic disorder, skin and eye disorders, and nephrotic syndrome. It provides relieve by preventing the release of substances that cause inflammation. Methylprednisolone Acetate should be taken with food. This will prevent you from getting an upset stomach. The dose and duration will depend on what you are being treated for. You should always take the amount prescribed. Do not take a larger dose or use it more often. Keep taking it regularly even if you feel well. Some conditions will become worse if you stop using this medicine. The most common side effects of this medicine include skin thinning, increased risk of infection, reduction in bone density, weight gain, and mood changes. If these side effects bother you or do not go away, your doctor may suggest ways of preventing or reducing them. Using of this medicine may lower your ability to fight infections so avoid being near people who might pass on infections such as measles, chickenpox, or flu and do not receive a live vaccine while using this medicine. Before using this medicine, you should tell your doctor if you have brittle bones (osteoporosis), mood disorders, high blood pressure, or liver disease. Also tell your doctor if you have diabetes, this medicine may increase blood glucose levels which can cause or worsen diabetes. Many other drugs may affect, or be affected by, this medicine so let your doctor know all other medicines you are using, to make sure it is safe. You should also tell your doctor if you are pregnant, planning to become pregnant or breastfeeding. Methylprednisolone Acetate is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

• Rheumatic disorder • Skin disorders • Eye disorders • Nephrotic syndrome • Systemic lupus erythematosus (SLE)

Methylprednisolone is a synthetic corticosteroid with mainly glucocorticoid activity and minimal mineralocorticoid properties. It decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.

Adult Dose: Intra-articular Anti-inflammatory or immunosuppressive Adult: As methylprednisolone acetate: 4-10 mg (small joints); 10-40 mg (medium joints); 20-80 mg (large joints). May be repeated every 1-5 wk depending on patient's response. Intralesional Anti-inflammatory or immunosuppressive Adult: As methylprednisolone acetate: 20-60 mg every 1-5 wk depending on patient's response. Corticosteroid-responsive dermatoses Adult: As methylprednisolone acetate: 20-60 mg is injected into the lesion; 1-4 inj may be given at intervals depending on the type of lesion and the duration of improvement from the initial inj. Intramuscular Administration for Systemic Effect Usual dosing range, 10-80 mg IM every 1-2 weeks; as temporary substitute for PO, given in daily IM dose equal to daily PO dose;for prolonged effect, given in weekly IM dose equal to 7 times daily PO dose; may not be given IV Adrenogenital syndrome a single intramuscular injection of 40 mg every two weeks may be adequate. For maintenance of patients with rheumatoid arthritis the weekly intramuscular dose will vary from 40 to 120 mg. Dermatologic lesions benefited by systemic corticoid therapy 40 to 120 mg of methylprednisolone acetate administered intramuscularly at weekly intervals for one to four weeks. Acute severe dermatitis due to poison ivy relief may result within 8 to 12 hours following intramuscular administration of a single dose of 80 to 120 mg. Chronic contact dermatitis repeated injections at 5 to 10 day intervals may be necessary. Seborrheic dermatitis a weekly dose of 80 mg may be adequate to control the condition. Asthmatic patients, Allergic rhinitis (hay fever) IM administration of 80 to 120 mg, relief may result within 6 to 48 hours and persist for several days to two weeks.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Methylprednisolone Acetate is to be taken with food. Avoid Methylprednisolone Acetate with dietary sodium.

Common: • Thinning of skin • Increased risk of infection • Reduction in bone density • Weight gain • Mood changes • Upset stomach • Behavioural changes

[UNSAFE] Methylprednisolone Acetate may cause side effects which could affect your ability to drive. Undesirable effects, such as dizziness, vertigo, visual disturbances and fatigue are possible after treatment with Methylprednisolone Acetate. This may affect your driving ability. Methylprednisolone Acetate helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system. Do not use it more often or for longer than advised by your doctor. Take it with food to avoid an upset stomach. Methylprednisolone Acetate can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat. Side effects such as mood changes or stomach problems can happen when you start taking Methylprednisolone Acetate. Inform your doctor if this bothers you. Do not stop taking Methylprednisolone Acetate suddenly without talking to your doctor first as it may worsen your symptoms.

Methylprednisolone acetate is contraindicated in patients with known hypersensitivity to the product and its constituents. Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura. Methylprednisolone acetate injectable suspension is contraindicated for intrathecal administration. Methylprednisolone acetate is contraindicated in systemic fungal infections, except when administered as an intra-articular injection for localized joint conditions

Loss of corticosteroid-induced adrenal suppression w/ aminoglutethimide. Risk of hypokalaemia w/ K-depleting agents (e.g. amphotericin B, diuretics). Decreased clearance w/ macrolide antibiotics. May decrease serum levels of isoniazid. Increased clearance w/ cholestyramine. Risk of convulsions w/ ciclosporin. Increased risk of arrhythmias w/ digitalis glycosides. Decreased metabolism w/ oestrogens, including OCs. Enhanced metabolism w/ CYP3A4 inducers (e.g. rifampicin, barbiturates). Increased plasma concentrations w/ CYP3A4 inhibitors (e.g. ketoconazole, erythromycin). Risk of GI effects w/ aspirin or other NSAIDs. May increase the anticoagulant effect of warfarin. May reduce the therapeutic effect of antidiabetics. Potentially Fatal: May diminish response to live or live, attenuated vaccines.

[UNSAFE] It is unsafe to consume alcohol with Methylprednisolone Acetate.

[CONSULT YOUR DOCTOR] Methylprednisolone Acetate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Methylprednisolone Acetate is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[SAFE IF PRESCRIBED] Methylprednisolone Acetate is safe to use in patients with kidney disease. No dose adjustment of Methylprednisolone Acetate is recommended. However, talk to your doctor if you have any underlying kidney disease. [CONSULT YOUR DOCTOR] There is limited information available on the use of Methylprednisolone Acetate in patients with liver disease. Please consult your doctor.

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