৳ 600/unit
Pack: ৳ 600
৳ 600/unit
Pack: ৳ 600
At a glance
Methylprednisolone is a potent corticosteroid used to treat inflammation, allergies, rheumatic disorders, skin and eye diseases, and nephrotic syndrome.
Indications
- Rheumatic Disorders (Rheumatoid Arthritis, Ankylosing Spondylitis, Gouty Arthritis)
- Collagen Diseases (Systemic Lupus Erythematosus, Dermatomyositis)
- Dermatologic Diseases (Pemphigus, Exfoliative Dermatitis, Psoriasis)
- Allergies (Bronchial Asthma, Contact Dermatitis)
- Ophthalmic Diseases (Iritis, Keratitis, Allergic Conjunctivitis)
- Respiratory Diseases (Sarcoidosis, Aspiration Pneumonitis)
- Hematologic Disorders (Idiopathic Thrombocytopenic Purpura, Hemolytic Anemia)
- Neoplastic Diseases (Leukemias, Lymphomas)
- Edematous States (Nephrotic Syndrome)
- CNS Diseases (Multiple Sclerosis)
- Endocrine Disorders (Adrenocortical Insufficiency)
Pharmacology
Methylprednisolone binds to and activates intracellular glucocorticoid receptors. Activated glucocorticoid receptors bind to promoter regions of DNA and activate transcription factors that result in gene inactivation through deacetylation of histones. It inhibits leukocyte infiltration at the site of inflammation, interferes with mediators of inflammatory response, and suppresses humoral immune responses.
Dosage
Adult Dose (Oral):
- Anti-inflammatory/Immunosuppressive: Initial: 4-48 mg daily (1-4 divided doses as needed)
- Allergic Conditions: 24 mg (Day 1), 20 mg (Day 2), 16 mg (Day 3), 12 mg (Day 4), 8 mg (Day 5), 4 mg (Day 6)
- Maintenance: Lowest effective dose based on patient response
- Multiple Sclerosis: 160 mg daily for 1 week, then 64 mg every other day for 1 month
Child Dose: 0.5-1.7 mg/kg daily or 5-25 mg/m² daily (6-12 hourly intervals)
Alternate-day therapy (ADT): Twice the daily dose every other morning (to minimize side effects in long-term use)
Side effects
Common Side Effects:
- Skin thinning
- Increased risk of infection
- Reduction in bone density
- Weight gain
- Mood changes
- Upset stomach
- Behavioral changes
Long-term/High-dose:
- Fluid retention, weight gain, hypertension
- Potassium loss, headache
- Muscle weakness, osteoporosis
- Glaucoma, cataracts
- Peptic ulcer, growth retardation (children)
- Convulsions, psychiatric disorders (depression, euphoria, insomnia)
Use in pregnancy
Use in Pregnancy (Category C): Possibly unsafe. Limited human studies; animal studies show harmful effects on developing baby. Your doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not stop abruptly (risk of adrenal insufficiency)
- Inform doctor if signs of infection (fever, sore throat) occur
- Do not receive live vaccines
- Monitor blood glucose if diabetic
- Caution in osteoporosis, mood disorders, hypertension, liver disease
- Enhanced effect in hypothyroidism and cirrhosis
Overdose effects
Reports of acute toxicity/death are rare. No specific antidote; supportive and symptomatic treatment. Monitor serum electrolytes.
Storage conditions
Store in a cool and dry place, away from light. Keep out of reach of children.